Relative Potency in Acute and Chronic Suppressive Effects of Prednisolone and Betamethasone on the Hypothalamic-Pituitary-Adrenal Axis in Man
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概要
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The relative potency in the hypothalamic-pituitary-adrenal (HPA) suppression of both prednisolone and betamethasone was examined in an acute study with normal volunteers and in a chronic study with glucocorticoid-treated patients. Circadian rhythm of plasma cortisol was studied after a single dose administration of 5 to 30 mg prednisolone or 0.5 to 3.0 mg betamethasone at 08:00 hr. Morning-rise of plasma cortisol occurred on the morning after the administration of 30 mg or less prednisolone but no morning rise was noted after the administration of 1.0 mg or more betamethasone. Plasma ACTH was slightly elevated on the morning after 30 mg prednisolone administration but showed low levels throughout the night after 3.0 mg betamethasone administration. Plasma cortisol responsiveness to ACTH was examined in patients before and during therapy with either prednisolone or betamethasone. The basal cortisol level was not suppressed and the responsivenessto ACTH remained nearly normal during long-term 5 mg prednisolone therapy, but these were completely suppressed during long-term 0.5 mg betamethasone therapy. The responsiveness to ACTH was nearly normal in patients receiving alternate-day therapy with prednisolone in such large doses as 50 or 60 mg every other day, but was completely suppressed in patients receiving 1.0 mg betamethasone every other day. The relative potency of betamethasone in acute and chronic suppressive effects on the HPA system seems to be much stronger than that of prednisolone inequivalent doses with comparable anti-inflammatory effects. It is also suggested that the alternate-day therapy with such long-acting steroids as betamethasone are useless in preventing HPA suppression.
- 社団法人 日本内分泌学会の論文
著者
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Yamamura Yuichi
The Third Department of Internal Medicine, Osaka University Medical School
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MORIMOTO YASUHIKO
The Third Department of Internal Medicine, Osaka University School of Medicine
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OISHI TATSUO
The Third Department of Internal Medicine, Osaka University School of Medicine
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HANASAKI NOBUO
The Third Department of Internal Medicine, Osaka University School of Medicine
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MIYATAKE AKIHIKO
The Third Department of Internal Medicine, Osaka University School of Medicine
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NOMA KEIZO
The Third Department of Internal Medicine, Osaka University School of Medicine
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MIYATAKE AKIHIKO
The Third Department of Internal Medicine, Osaka University Medical School
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YAMAMURA YUICHI
The Third Department of Internal Medicine, Osaka University School of Medicine
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YAMAMURA YUICHI
The Third Department of Internal Medicine, Medical School of Osaka University
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HANASAKI NOBUO
The Third Department of Internal Medicine, Medical School of Osaka University
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