Synthesis and Physiological Activity of Novel Tocopheryl Glycosides
スポンサーリンク
概要
- 論文の詳細を見る
Vitamin E glycosides were synthesized and enzymatic hydrolysis was examined for use as potential prodrugs, however, the glycoside bond was found to be stable. On the other hand, among the glycosides synthesized, dl-α-tocopherylglucoside(6b)and al-α-tocopherylmannoside(6c)showed strong inhibitory action on histamine release from mast cells. In addition, 6c also showed a suppressive action on IgE antibody formation. Thus, tocopheryl glycoside showed new properties compared to tocopherol(vitamin E). In particular, 6c was shown to be a novel lead compound with excellent manifold anti-allergic activity and anti-inflammatory activity.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
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Satoh Toshio
Department of Biological Science, Faculty of Science, Hiroshima University
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Hirano T
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Satoh T
Yakuhan Pharmaceutical Co. Ltd. Hokkaido Jpn
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HIRANO Takashi
Department of Applied Physics and Chemistry, The University of Electro-Communications
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Satoh Toshio
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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MIYATAKA Hideki
Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri U
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YAMAMOTO Kyozo
Department of Bio-organic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri U
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Yamamoto Kyozo
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Hirano Takashi
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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