Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-.BETA.-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-(1,5-a) pyridine (KC-404).
スポンサーリンク
概要
- 論文の詳細を見る
Effects of 2-methyl-3-piperidino-β-propionaphtone hydrochloride (KZ-111), 3-isobutyryl-2-isopropylpyrazolo-[1, 5-a]pyridine (KC-404) and FPL-55712 on experimental allergic reactions were investigated. Homologous passive cutaneous anaphylaxis (PCA) in rats was clearly inhibited by oral and intravenous administrations of KC-404 and KZ-111. FPL-55712 inhibited the PCA reaction only by intravenous injection, but not by oral administration. Maximum inhibition of the PICA reaction by KC-404 and KZ-111 was obtained by administration of these agents 2 hr prior to challenge. The immunological release of histamine from sensitized rat peritoneal mast cells was inhibited by KZ-111 at a concentration of 10<SUP>-4</SUP> g/ml. KC-404 and FPL-55712 did not inhibit the immunological release of histamine. All three compounds had no effect on the release of histamine from rat peritoneal mast cells and on the generation of SRS from rat polymorphonuclear leucocytes by calcium ionophore A23187. KC-404 and KZ-111 produced a downward displacement of the maximum without a parallel shift in LTD<SUB>4</SUB> induced concentration-response curves of guinea pig ileal and tracheal smooth muscle at concentrations between 10<SUP>-6</SUP> and 10<SUP>-5</SUP> g/ml. FPL-55712 at a concentration of 10<SUP>-6</SUP> g/ml produced a parallel shift of LTD<SUB>4</SUB> induced concentration-response curves to the right in both smooth muscle preparations. The 50% inhibitory concentration to the contraction by LTD<SUB>4</SUB> of each of the three compounds is lower than those of other agonists, histamine, PGF<SUB>2α</SUB> and BaCl<SUB>2</SUB>. KC-404 and KZ-111 inhibited CaCl<SUB>2</SUB>-induced contraction in K<SUP>+</SUP>-depolarized ileal smooth muscle, but FPL-55712 had no effect on the CaCl<SUB>2</SUB>-induced contraction. All three compounds inhibited the Schultz-Dale reaction in guinea pig trachea. Respiratory disorder in guinea pig experimental asthma was inhibited by oral administration of KC-404 and KZ-111, but not by FPL-55712.
- 公益社団法人 日本薬理学会の論文
著者
-
Nishiyori Takeshi
Department Of Pharmacology Gifu Pharmaceutical University
-
Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
-
IWAMOTO TEIJI
Department of Pharmacology, Gifu Pharmaceutical University
-
Tsuchiya Hiroshi
Department Of Chemical Engineering Nagoya University
-
Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
-
NAGAI Hiroichi
Department of Pharmacology, Gifu College of Pharmacy
-
TAKIZAWA Tamotsu
Department of Pharmacology, Gifu College of Pharmacy
-
IWAMOTO Teiji
Department of Pharmacology, Gifu College of Pharmacy
-
NISHIYORI Takeshi
Department of Pharmacology, Gifu College of Pharmacy
関連論文
- 185 霊芝の抗アレルギー作用についての検討(動物モデル6,第58回日本アレルギー学会秋季学術大会)
- 9 気管支喘息の病態形成における陰イオン輸送体Pendrinの役割(気管支喘息-病態生理2,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- MS5-5 ダニ抗原誘発アレルギー性気道炎症に対する二本鎖RNAの影響(動物モデルによる解析,ミニシンポジウム,一般演題,第18回日本アレルギー学会春季臨床大会)
- P55 OVA感作したBALB/cマウスにおけるLactobacillus acidophilus Strain L-92の抗アレルギー効果の検討(IgE関連,ポスターセッション,一般演題,第18回日本アレルギー学会春季臨床大会)
- MS33-#4 ホルムアルデヒド誘発マウス皮膚炎モデルにおけるtransient receptor potential vanilloid1(TRPV1)の意義(アレルゲン・抗原と症例2,第59回日本アレルギー学会秋季学術大会)
- 178 アレルギー性気道炎症におけるCRTH2の意義(動物モデル8,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- 177 ダニ抗原誘発マウス気道炎症におけるCRTH2の意義(動物モデル8,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- 163 マウス肥満細胞からのIgE依存性ヒスタミン遊離に及ぼすprostaglandin D_2の影響(肥満細胞,好塩基球2,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- S7-4 揮発性有機化合物の反復塗布によるマウス皮膚炎モデルの解析(化学物質過敏症の実態と対策, 第19回日本アレルギー学会春季臨床大会)
- MS33-#2 微生物由来揮発性有機化合物の皮膚に及ぼす影響に関する基礎的研究(アレルゲン・抗原と症例2,第59回日本アレルギー学会秋季学術大会)
- MS21-12 L acidophilus L92 Inhibits PCA and ACA as well as DNFB and Mite Antigen Induced Dermatitis in Mice
- MS16-9 ダニ抗原誘発マウス気道炎症におけるProtease-activated receptor(PAR)2の意義(気管支喘息-動物モデル1,第59回日本アレルギー学会秋季学術大会)
- SL8 患者に優しいアレルギー治療のための新薬とその開発 : 天然物からの創薬(特別講演8,第21回日本アレルギー学会春季臨床大会)
- 1年生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析
- 186 マウスアレルギー性皮膚炎に及ぼす抗アレルギー薬loratadineの影響(動物モデル6,第58回日本アレルギー学会秋季学術大会)
- 179 ホルムアルデヒド(FA)反復塗布誘発マウス皮膚炎モデルにおける侵害刺激受容体の影響(動物モデル4,第58回日本アレルギー学会秋季学術大会)
- 52 マウス骨髄由来肥満細胞(BMMC)からのIgE依存性ヒスタミン遊離に及ぼすprostaglandin D_2 (PGD_2)の影響(マスト細胞,好塩基球2,第58回日本アレルギー学会秋季学術大会)
- 43 ダニ抗原誘発マウス気道炎症の解析(2)(動物モデル2,第58回日本アレルギー学会秋季学術大会)
- MS6-5 ダニ抗原誘発マウス気道炎症の解析(1)(アレルゲン/抗原,第58回日本アレルギー学会秋季学術大会)
- MS5-7 ダニ抗原反復塗布によるマウスアトピー性皮膚炎モデルの作成(気管支喘息-動物モデル,第58回日本アレルギー学会秋季学術大会)
- MS5-1 ダニ抗原によるマウス気道炎症の解析(3)(気管支喘息-動物モデル,第58回日本アレルギー学会秋季学術大会)
- S1-5 実験喘息の立場から(気管支喘息の難治化機構とその対策,第58回日本アレルギー学会秋季学術大会)
- 417 フローサイトメトリー法によるBALF中の細胞分類計数について : その2(動物モデル11,一般演題(口演),第56回日本アレルギー学会秋季学術大会)
- 390 ダニ抗原誘発アレルギー性気道炎症モデルに対するCpGモチーフの効果(動物モデル8,一般演題(口演),第56回日本アレルギー学会秋季学術大会)
- 386 ダニ抗原誘発マウス気道炎症におけるTh2サイトカインの意義(2)(動物モデル7,一般演題(口演),第56回日本アレルギー学会秋季学術大会)
- 385 ダニ抗原誘発マウス気道炎症におけるTh2サイトカインの意義(1)(動物モデル7,一般演題(口演),第56回日本アレルギー学会秋季学術大会)
- 司会のことば(アレルギー疾患と炎症・リモデリング,第58回日本アレルギー学会秋季学術大会)
- 514 ダニ抗原によるマウス気道リモデリングに及ぼすディーゼル排気粒子(DEP)の影響(動物モデル(8), 第55回日本アレルギー学会秋季学術大会)
- OE-331 Dynamic Binding of Nuclear Matrix Proteins to Chromatin DMA Induced by cyclic Stretch in Rat Cardiovascular Cells(Molecular biology, myocardium-1 (M) OE56,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- 20-P3-510 1回生「薬を使う薬学」PBLテュートリアルの実施とプロダクト発表に対する評価の分析(薬学教育(モデル・コアカリキュラム),来るべき時代への道を拓く)
- Lactobacillus Acidophilus Strain L-92 Regulates the Production of Th1 Cytokine as well as Th2 Cytokines
- Production of Matrix Metalloproteinases in Human Cultured Mast Cells : Involvement of Protein Kinase C-Mitogen Activated Protein Kinase Kinase-Extracellular Signal-regulated Kinase Pathway
- Establishment of Allergic Dermatitis in NC/Nga Mice as a Model for Severe Atopic Dermatitis(Pharmacology)
- The Effect of a Newly Synthesized Indazole Compound, TAS-3-124, on Experimental Autoimmune Disease(Pharmacology)
- Role of T cells in IgE-dependent triphasic cutaneous reaction caused by dinitrofluorobenzene in the mouse ear : Participation of CD8^+ T cells
- P-53 Effects of Vaticanol (B, C and G), α-Viniferin and Hopeaphenol on the Release of Mediators from Bone Marrow-Derived Mast Cells
- Effect of Estrogen Replacement Therapy on Hepatic Triglyceride Lipase, Lipoprotein Lipase and Lipids Including Apolipoprotein E in Climacteric and Elderly Women
- アレルギー治療薬の現状と未来
- Differential Effects of β_2-Adrenoceptor Desensitization on the IgE-Dependent Release of Chemical Mediators from Cultured Human Mast Cells(Pharmacology)
- Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
- Recovery of Purification-Associated Reduction in Antigen-Induced Histamine Release from Rat Peritoneal Mast Cells
- Terreic acid, a Quinone Epoxide Inhibitor of Bruton's Tyrosine Kinase.
- Effect of Mizoribine on Effector T Cell-Mediated Immune Responses in Mice
- Effects of a New Antiallergic Drug, VUF-K-8788, on Infiltration of Lung Parenchyma by Eosinophils in Guinea Pigs and Eosinophil-Adhesion to Human Umbilical Vein Endothelial Cells(HUVEC)
- Psychosocial stress enhances IgE-mediated triphasic cutaneous reaction in mice : Antagonism by Yokukan-san (a Kampo medicine) and diazepam
- A Kampo Formulation : Byakko-ka-ninjin-to(Bai-Hu-Jia-Ren-Sheng-Tang)Inhibits IgE-Mediated Triphasic Skin Reaction in Mice : The Role of Its Constituents in Expression of the Efficacy
- Inhibitory Mechanisms of Glycoprotein Fraction Derived from Miscanthus sinensis for the Immediate Phase Response of an IgE-Mediated Cutaneous Reaction
- Osmotic Dehydration of Bentonite Slurry Using Hypertonic Polymer Solution
- Effects of Sho-seiryu-to (Xiao-Qing-Long-Tang) on experimental allergic reactions
- 222. Experimental Study on Drug-induced Contact Dermatitis as a Model Using p-Phenylendiamine (The Second Meeting for the Study of Toxic Effect)
- Effect of Estrogen and Progesterone on Gene Expression of Growth Regulatory Molecules and Proto-Oncogene in Vascular Smooth Muscle Cells
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Pharmacological Study of Phospholipase A_2-Induced Histamine Release from Rat Peritoneal Mast Cells
- Evaluation of Anti-allergic Effects of 1-Substituted 2-n-Butyl-methylenedioxy Indenes
- Mental Stress Inhibits the Intimal Fibromuscular Proliferation through Endogenous Opioid System in the Process of Arterial Remodeling
- Studies on the Anti-allergic Mechanism of Glucocorticoids in Mice
- SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
- IMMUNOGLOBULIN E ANTIBODY PRODUCTION AGAINST HOUSE DUST MITE, DERMATOPHAGOIDES FRARINAE, IN MICE
- Effect of CV-3988,a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Immunotoxicity of Triphenyltin Chloride in Mice
- Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
- Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs
- Effect of a Non-Protein Fraction from an Extract of the Inflamed Skin of Rabbits Inoculated with Vaccinia Virus (Neurotropin) on Meth A-Induced Delayed Type Hypersensitivity
- The effects of TYB-2285 and its metabolites on eosinophil adhesion to tumor necrosis factor α-stimulated human umbilical vein endothelial cells
- EFFECT OF 1, 3-BIS (2-PHENYL-4-CHROMENON-5-YL)-2-OL ON EXPERIMENTAL ASTHMA IN GUINEA PIGS
- HISTAMINE RELEASE FROM RAT NEUTROPHILS AND MAST CELLS AS INDUCED BY IONOPHORE —A PHARMACOLOGICAL APPROACH—
- INHIBITION OF HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS (PCA) BY DISODIUM CROMOGLYCATE-RELATED COMPOUNDS
- PHARMACOLOGICAL STUDIES ON THE RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS DURING ANTI-IMMUNOGLOBULIN E ANTIBODY MEDIATED PASSIVE PERITONEAL ANAPHYLAXIS IN RATS
- EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
- Comparative Study of 1.5-Hour and 48-Hour Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Effect of Substance P on the Antigen-Induced Bronchoconstriction in Guinea Pigs
- A COMPARATIVE STUDY OF THE ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM CROMOGLYCATE (DSCG)
- STUDIES ON THE MECHANISMS OF THE INHIBITORY EFFECT OF N-5 ON HISTAMINE RELEASE FROM RAT PERITONEAL EXUDATE CELLS
- THE SUSCEPTIBILITY OF EXPERIMENTAL GLOMERULONEPHRITIS IN SIX DIFFERENT STRAINS OF MICE
- ANTI-TUMOR EFFECT OF NEW 5-FLUOROURACIL DERIVATIVES AND THEIR INFLUENCES ON THE IMMUNE RESPONSE
- Antitumor Activity of Two Novel Low Immunosuppressive Fluoropyrimidines UK-21 and UK-25.
- Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-.BETA.-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-(1,5-a) pyridine (KC-404).
- Experimental glomerulonephritis in mice as a model for immunopharmacological studies.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.
- Anti-allergic action of glucocorticoids in rats.
- Mechanisms of antiumor activity of aqueous extracts from chinese herbs: Their imunopharmacological properties.
- Active Principle of Swine Prostate Extract: II. Effect of a Peptide Isolated from Swine Prostate Extract on Rat Prostate.
- Potent inhibitory activity of HSR-6071, a new antiallergic agent, on Passive Cutaneous Anaphylaxis(PCA).
- Active Principle of Swine Prostate Extract:I. Isolation of Active Principle Activating Prostatic Acid Phosphatase and Its Effect on Testosterone Uptake of the Prostate in Castrated Rats.
- The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
- Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
- Inhibition of IgE antibody formation by n-pentyl .ALPHA.-L-sorbopyranoside.
- Mechanisms for Glucocorticoid Inhibition of Immediate Hypersensitivity Reactions in Rats.
- INHIBITION OF HYPERSENSITIVITY REACTIONS BY SOLUBLE DERIVATIVES OF BAICALEIN
- Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Effects of MKS-492 on Antigen-Induced Bronchoconstriction and Allergic Reaction in Guinea Pigs and Rats.
- Effect of N-5' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.
- Liver injury model in mice for immunopharmacological study.
- Effect of Three Novel K+ Channel Openers, Cromakalim, Pinacidil and Nicorandil on Allergic Reaction and Experimental Asthma.
- Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: meth A-induced delayed type hypersensitivity.
- Effect of OKY-046 and ONO-3708 on liver injury in mice.
- Immunopharmacological studies of sodium copper chlorphyllin (SCC).