Effect of a Non-Protein Fraction from an Extract of the Inflamed Skin of Rabbits Inoculated with <I>Vaccinia</I> Virus (Neurotropin) on Meth A-Induced Delayed Type Hypersensitivity
スポンサーリンク
概要
- 論文の詳細を見る
The effect of a non-protein fraction from an extract of inflamed skin of rabbits inoculated with <I>vaccinia</I> virus (Neurotropin, NSP) was studied on Meth A tumor-induced delayed type hypersensitivity (Meth A-DTH) in BALB/c mice. NSP enhanced the Meth A-DTH. NSP also enhanced the DTH suppressed with 5-fluorouracil (5-FU). Moreover, NSP inhibited the fatal effect of 5-FU and restored the decrease of body weight caused by 5-FU. However, NSP reduced partially but significantly the suppression of the tumor growth by 5-FU. NSP may be useful for cancer treatment in combination with chemotherapeutic agents, if NSP does not inhibit their antitumor activity.
著者
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Xu Qiang
Department Of Chemical Engineering Tsinghua University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
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XU Qiang
Department of Pharmacology, Gifu Pharmaceutical University
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KURIMOTO Yoshiyuki
Department of Pharmacology, Gifu Pharmaceutical University
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KURIMOTO Yoshiyuki
Department of Immunology and Allergy, Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Company
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