Effect of N-5' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP.
スポンサーリンク
概要
- 論文の詳細を見る
We studied the effect of N-(3, 4-dimethoxycinnamoyl)anthranilic acid (N-5'), an orally applicable anti-allergic drug, on the histamine release induced by calcium ionophores (A23187 and X537A) and ATP from rat peritoneal exudate cells (PEC). X537A (0.1-33.3 μg/ml) induced histamine release in a concentrationrelated manner, and 2.0 μg/ml of X537A induced release to the same extent as allergic histamine release. Histamine release induced by 2.0 μg/ml of X537A increased with longer incubation time, reaching a peak of about 100% at 120 min. N-5' had no effect on histamine release induced by X537A at the concentrations used (1-1000 μM), but DSCG exhibited significant inhibition at 1-100 μM. A23187 (0.05-0.5 μg/ml) induced histamine release in a concentration-related manner, and it seemed that 0.033 μg/ml of A23187 induces the same degree of histamine release as the allergic one. A23187 induced rapid histamine release which attained maximum 1 min after the addition. N-5' exhibited a significant concentration-dependent inhibitory effect on histamine release induced by A23187, and DSCG also exhibited significant inhibition (10 and 1000 μM). N-5' significantly inhibited histamine release induced by 100 μM ATP. These results indicate that N-5' and DSCG effect the histamine release induced by lonophore A23187 and X537A by different manners, and they suggest the possibility that N-5' inhibits some Ca<SUP>++</SUP>-dependent processes in histamine release, including the influx of Ca<SUP>++</SUP> into cells, which is a trigger of the A23187 and ATP effects.
- 公益社団法人 日本薬理学会の論文
著者
-
Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
-
UJIIE Arao
Division of Pharmacology, Research Laboratories, Kissei Pharmaceutical Co., Ltd.
-
NAITO Jun
Division of Pharmacology, Research Laboratories, Kissei Pharmaceutical Co., Ltd.
-
NAKAZAWA Masayuki
Division of Pharmacology, Research Laboratories, Kissei Pharmaceutical Co., Ltd.
-
KOJIMA Masami
Division of Pharmacology, Research Laboratories, Kissei Pharmaceutical Co., Ltd.
関連論文
- 222. Experimental Study on Drug-induced Contact Dermatitis as a Model Using p-Phenylendiamine (The Second Meeting for the Study of Toxic Effect)
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Pharmacological Study of Phospholipase A_2-Induced Histamine Release from Rat Peritoneal Mast Cells
- Evaluation of Anti-allergic Effects of 1-Substituted 2-n-Butyl-methylenedioxy Indenes
- Studies on the Anti-allergic Mechanism of Glucocorticoids in Mice
- SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
- IMMUNOGLOBULIN E ANTIBODY PRODUCTION AGAINST HOUSE DUST MITE, DERMATOPHAGOIDES FRARINAE, IN MICE
- Effect of CV-3988,a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Immunotoxicity of Triphenyltin Chloride in Mice
- Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
- Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs
- Effect of a Non-Protein Fraction from an Extract of the Inflamed Skin of Rabbits Inoculated with Vaccinia Virus (Neurotropin) on Meth A-Induced Delayed Type Hypersensitivity
- The effects of TYB-2285 and its metabolites on eosinophil adhesion to tumor necrosis factor α-stimulated human umbilical vein endothelial cells
- EFFECT OF 1, 3-BIS (2-PHENYL-4-CHROMENON-5-YL)-2-OL ON EXPERIMENTAL ASTHMA IN GUINEA PIGS
- HISTAMINE RELEASE FROM RAT NEUTROPHILS AND MAST CELLS AS INDUCED BY IONOPHORE —A PHARMACOLOGICAL APPROACH—
- INHIBITION OF HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS (PCA) BY DISODIUM CROMOGLYCATE-RELATED COMPOUNDS
- PHARMACOLOGICAL STUDIES ON THE RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS DURING ANTI-IMMUNOGLOBULIN E ANTIBODY MEDIATED PASSIVE PERITONEAL ANAPHYLAXIS IN RATS
- EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
- Comparative Study of 1.5-Hour and 48-Hour Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Effect of Substance P on the Antigen-Induced Bronchoconstriction in Guinea Pigs
- A COMPARATIVE STUDY OF THE ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM CROMOGLYCATE (DSCG)
- STUDIES ON THE MECHANISMS OF THE INHIBITORY EFFECT OF N-5 ON HISTAMINE RELEASE FROM RAT PERITONEAL EXUDATE CELLS
- THE SUSCEPTIBILITY OF EXPERIMENTAL GLOMERULONEPHRITIS IN SIX DIFFERENT STRAINS OF MICE
- ANTI-TUMOR EFFECT OF NEW 5-FLUOROURACIL DERIVATIVES AND THEIR INFLUENCES ON THE IMMUNE RESPONSE
- Antitumor Activity of Two Novel Low Immunosuppressive Fluoropyrimidines UK-21 and UK-25.
- Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-.BETA.-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-(1,5-a) pyridine (KC-404).
- Experimental glomerulonephritis in mice as a model for immunopharmacological studies.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.
- Anti-allergic action of glucocorticoids in rats.
- Mechanisms of antiumor activity of aqueous extracts from chinese herbs: Their imunopharmacological properties.
- Active Principle of Swine Prostate Extract: II. Effect of a Peptide Isolated from Swine Prostate Extract on Rat Prostate.
- Potent inhibitory activity of HSR-6071, a new antiallergic agent, on Passive Cutaneous Anaphylaxis(PCA).
- Active Principle of Swine Prostate Extract:I. Isolation of Active Principle Activating Prostatic Acid Phosphatase and Its Effect on Testosterone Uptake of the Prostate in Castrated Rats.
- The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
- Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
- Inhibition of IgE antibody formation by n-pentyl .ALPHA.-L-sorbopyranoside.
- Mechanisms for Glucocorticoid Inhibition of Immediate Hypersensitivity Reactions in Rats.
- INHIBITION OF HYPERSENSITIVITY REACTIONS BY SOLUBLE DERIVATIVES OF BAICALEIN
- Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Effects of MKS-492 on Antigen-Induced Bronchoconstriction and Allergic Reaction in Guinea Pigs and Rats.
- Effect of N-5' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.
- Liver injury model in mice for immunopharmacological study.
- Effect of Three Novel K+ Channel Openers, Cromakalim, Pinacidil and Nicorandil on Allergic Reaction and Experimental Asthma.
- Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: meth A-induced delayed type hypersensitivity.
- Effect of OKY-046 and ONO-3708 on liver injury in mice.
- Immunopharmacological studies of sodium copper chlorphyllin (SCC).