Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: meth A-induced delayed type hypersensitivity.
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概要
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In the present paper, we confirmed that a delayed type hypersensitivity response can be elicited against Meth A tumor (Meth A-DTH) in BALB/c mice bearing the primary tumor. This response was augmented by lipopolysaccharide. We examined the effects of 4 kinds of Chinese herbs including <I>A. capillans, S. doederleinii, A. macrocephala</I> and <I>S. subprostrata</I> on the Meth A-DTH, and the results were compared with that of the herbs on picryl chloride-induced delayed type hypersensitivity (PC-DTH). All of the herbs examined augmented the Meth A-DTH 10 days after the primary tumor transplantation, and <I>S. doederleinii, A. macrocephala</I> and <I>S. subprostrata</I> prevented the decay of the response on the 20th day, but <I>A. capillaris</I> did not. On the other hand, none of the herbs affected the PC-DTH. When both DTH responses were caused simultaneously in the same mouse, Meth A-DTH decayed 20 days after the transplantation but PC-DTH did not. In this case, the effects of these 4 herbs on Meth A-DTH and PC-DTH were essentially the same as those seen in the case of separate experiments. The previous and present results suggest that <I>A. capillans</I> shows antitumor activity mainly through a direct cytotoxicity, although this herb might have certain components to enhance Meth A-DTH, and the other herbs display the activity through the enhancement of T cell-mediated tumor immunity, particularly tumor specific DTH.
- 公益社団法人 日本薬理学会の論文
著者
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Xu Qiang
Department Of Chemical Engineering Tsinghua University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Nishioka Itsuo
Department Of Forestry Faculty Of Agriculture Kyushu University
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Ono Yutaka
Department Of Aeronautics And Astronautics University Of Tokyo
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Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
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SAKAMOTO Osami
Department of Pharmacology, Gifu Pharmaceutical University
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UESUGI Yuki
Department of Pharmacology, Gifu Pharmaceutical University
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