Effects of ACNU and Cranial Irradiation on the Mouse Immune System
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概要
- 論文の詳細を見る
The effects of ACNU and cranial irradiation on the immune system were studied in three groups of 90 mice: Group A, intraperitoneal injection of ACNU (30mg/kg); Group B, single exposure of 10 Gy to the head; and Group C, intraperitoneal injection of ACNU (30mg/kg) and single exposure of 10 Gy to the head. Peripheral white blood cell counts, spleen cell subsets, natural killer (NK) cell activity, lymphocyte blastogenesis, and production of interferon (IFN)-y were analyzed once a week for 6 weeks after treatment. In Group A, NK cell activity decreased between weeks 4-5, concanavalin A blastogenesis decreased during weeks 1-5, and the levels of L3T4 (CD4) and Lyt2 cells (CD8) and IFN-y production decreased during weeks 2-5. However, all tested parameters returned to the normal range at 6 weeks. In Group B, all parameters except for the L3T4 cell level and the IFN-y production decreased during week 1, and returned to the normal range thereafter. The concentration of L3T4 cells decreased during week 2 and between weeks 5-6. The IFN-y production increased during week 1, decreased during week 2, and returned to the normal range thereafter. In Group C, the suppressive effects were severe and continued for a longer period than in either Group A or B. Concanavalin A blastogenesis, L3T4 cell concentration, and IFN-y production were still suppressed after 6 weeks. Therefore, intensive radiochemotherapy for brain tumor may suppress the immunological function.
- 日本脳神経外科学会の論文
- 1993-02-15
著者
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MORI Hiroshi
Department of Pharmacology, Gifu Pharmaceutical University
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Yoshida Seiichi
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Mori Hiroshi
Department Of Architecture Graduate School Of Engineering Nagoya University
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TAKEDA NORIO
Department of Applied Microbial Technology, Kumamoto Institute of Technology
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TANAKA Ryuichi
Department of Neurosurgery, Brain Research Institute, Niigata University
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Yoshida Seiichi
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takeda Norio
Department Of Neurosurgery Brain Research Institute Niigata University
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Takeda Norio
Department Of Applied Microbial Technology Kumamoto Institute Of Technology
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Tanaka Ryuichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Yamanaka Ryuya
Department Of Neurosurgery Brain Research Institute Niigata University
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SATOH Mitsuya
Department of Neurosurgery, Brain Research Institute, Niigata University
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Satoh Mitsuya
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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Tanaka Ryuichi
Department Of Liberal Arts Faculty Of Science And Technology Tokyo University Of Science
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Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
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YAMANAKA Ryuya
Department of Neurosurgery, Brain Research Institute, Niigata University
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