An autopsy case of Pick's disease and mini-review of the literature

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The authors report a case of a Pick's disease which was at first diagnosed as residual schizophrenia. The patient received the diagnosis of Pick's disease three years later based on a CT scan which showed cerebral atrophy, and died from pneumonia about ten years after the onset. Autopsy revealed cerebral atrophy in the frontal and temporal lobes and histologically many Pick bodies were observed in the cortex and hippocampus. Pick bodies were examined immunohistochemically and ultrastructually. The necessity of Pick bodies to diagnose Pick's disease has been a source of contention since this disease was first named, so Pick's disease continues to be investigated by new methods. From image-based method of diagnosis, new clinicopathological diagnostic criteria for frontotemporal dementia was proposed. Additionally, Pick's disease is a member of the classification of diseases known as tauopathy, based upon the concept of abnormal protein accumulation in the brain. The recent classification should be referred to make accurate diagnosis to this kind of diseases.
藍野大学の論文