Mechanisms of antiumor activity of aqueous extracts from chinese herbs: Their imunopharmacological properties.
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概要
- 論文の詳細を見る
Previously we reported the antitumor activity of 4 kinds of Chinese herbs: <I>A. capillaris, S. doederleinii, A. macrocephala</I> and <I>S. subprostrata</I>. Evidence has been also presented that <I>A. capillaris</I> shows the activity mainly through a direct tumoricidal action and the others display the activity through the enhancement of tumor-immune response. The present results are as follows: <I>A. capillaris</I> did not affect Meth A tumor-neutralizing activity (Winn's assay) in spleen cells of BALB/c mice bearing the primary tumor. The other herbs enhanced the activity on days 10 and 15 and prevented the decay of the activity on day 20 after the Meth A tumor transplantation. However, none of them enhanced the local graft versus host reaction (GvHR) induced in CBF<SUB>1</SUB> mice by spleen cells of BALB/c mice. <I>A. capillaris</I> hardly affected the humoral antibody formation against sheep red blood cells in mice. On the contrary, the other 3 herbs enhanced the formation. Blast transformation of murine lymphocytes with PHA-P or LPS was suppressed by 10<SUP>-5</SUP> to 10<SUP>-4</SUP> g/ml of <I>A. capillaris. A. macrocephala</I> enhanced the response by LPS. It should be noted that <I>A. capillaris</I> showed no immunosuppressive action in spite of having a direct tumoricidal action in vitro. Further investigations will be required on the latter 3 herbs to clarify the relationship between their humoral immunity-stimulating activity and their tumor immunity-enhancing activity.
- 公益社団法人 日本薬理学会の論文
著者
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Xu Qiang
Department Of Chemical Engineering Tsinghua University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Nishioka Itsuo
Department Of Forestry Faculty Of Agriculture Kyushu University
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Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
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KODA AKIHIDE
Department of Pharmacology, Gifu Pharmaceutical University
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SAKAMOTO Osami
Department of Pharmacology, Gifu Pharmaceutical University
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UESUGI Yuki
Department of Pharmacology, Gifu Pharmaceutical University
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NISHIOKA Itsuo
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Kyushu University
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