Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.
スポンサーリンク
概要
- 論文の詳細を見る
The activity of cyclic AMP-dependent protein kinase (protein kinase A) in the sensitized rat mast cell was decreased 2 min after antigen challenge when the histamine release exhibited a maximum. Drugs inhibiting allergic mediator release such as disodium cromoglycate, tranilast and theophylline significantly inhibited antigen-induced histamine release and reduced a decrease in the activity of protein kinase A. These results suggest that protein kinase A is involved in the histamine releasing process in the mast cell, and drugs inhibiting allergic mediator release cause their effects partially through the inhibition of protein kinase A.
- 公益社団法人 日本薬理学会の論文
著者
-
Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
-
Mori Hiroshi
Department Of Applied Physics Okayama University Of Science
-
Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
-
KUROSAWA Motohiro
1st Department of Internal Medicine, Faculty of Medicine, Gunma University
関連論文
- Isometric immersions of Euclidean plane into Euclidean 4-space with vanishing normal curvature
- ＜Symposium IV＞Oligomeric Aβ is the sole culprit molecule to cause Alzheimer's disease?
- Effect of Mizoribine on Effector T Cell-Mediated Immune Responses in Mice
- Terbutaline-Induced Triphasic Changes in Volume of Rat Alveolar Type II Cells:The Role of cAMP
- Correlation between the temperature of molten state and the SH intensity of 30BaO・15TiO_2・55GeO_2 crystallized glass
- SIMULATION OF CONSISTENCY TESTS FOR HIGH-FLUIDITY CONCRETE BY VISCOPLASTIC DIVIDED SPACE ELEMENT METHOD
- EXPERIMENTAL AND ANALYTICAL STUDIES ON PROPAGATION OF VIBRATION IN FRESH CONCRETE
- MICROSCOPIC STUDY ON VISCO-ELASTIC LIMIT OF CEMENTITIOUS MATERIALS
- STUDY ON INFLUENCE OF VARIOUS ADDITIVES ON SEGREGATION RESISTIVITY OF FRESH CONCRETE
- A STUDY ON EFFECT OF SUPERFINE POWDERS ON FLUIDITY OF CEMENT PASTE
- ANALYTICAL STUDY ON VIBRATION TRANSMISSION PROPERTIES OF FRESH CONCRETE
- STUDY ON CASTING OF HIGH-FLUIDITY CONCRETE INTO MIDDLE-SIZE WALL FORMS
- FUNDAMENTAL STUDY ON FLOWING PROCESS OF MAIRIX MORTAR BASED ON FILTRATION THEORY
- MODEL ANALYSIS ON EFFECT OF MICRO PARTICLE ON FAILURE PROPERTIES OF CONCRETE
- ANALYTICAL STUDY ON DYNAMIC PROPERTIES OF CONCRETE UNDER HIGH-SPEED COMPRESSIVE LOADING
- FLOW SIMULATION OF FRESH CONCRETE CAST INTO WALL STRUCTURE BY VISCOPLASTIC DIVIDED SPACE ELEMENT METHOD
- EXPERIMENTAL STUDY ON ADHESIVE AND HIGH SPEED SLIPPING PROPERTIES OF VISCOPLASTIC MATERIALS
- FUNDAMENTAL STUDY ON SEGREGATION RESISTIVITY OF FRESH CONCRETE
- ANALYTICAL STUDY ON TENSILE AND BENDING FAILURES OF CONCRETE BY VISCO-ELASTO-PLASTIC SUSPENSION ELEMENT METHOD
- 222. Experimental Study on Drug-induced Contact Dermatitis as a Model Using p-Phenylendiamine (The Second Meeting for the Study of Toxic Effect)
- Studies on Anti-allergic Action of AH 21-132, a Novel Isozyme-Selective Phosphodiesterase Inhibitor in Airways
- Autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach
- Ultrastructural study on cytotoxic effects of cyclosporine A in spermiogenesis in rats
- Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome
- Chordoma in the Sella Turcica
- Tau protein is a potential biological marker for normal pressure hydrocephalus
- Lipomatous pleomorphic adenoma of the ceruminous gland
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Synovial sarcoma arising from the pleura : a case report with ultrastructural and immunohistological studies
- Pharmacological Study of Phospholipase A_2-Induced Histamine Release from Rat Peritoneal Mast Cells
- Extracerebral ectopic mass with huge cysts in the anterior cranial cavity
- Symptomatic Child Case of Subependymoma in the Fourth Ventricle without Hydrocephalus
- Evaluation of Anti-allergic Effects of 1-Substituted 2-n-Butyl-methylenedioxy Indenes
- Effects of ACNU and Cranial Irradiation on the Mouse Immune System
- Duct-acinar-islet cell tumor of the pancreas
- Clinical Findings in Japanese Patients with Waardenburg Syndrome Type 2
- Visual Evoked Potentials Elicited by Pseudorandom Stimulation from Patients with Macular Degeneration
- Endometrial Cancer of the Uterus in a Patient with Spinal Cord Injury
- Restoration of Leydig cells after repeated administration of ethane dimethanesulfonate in adult rats
- The Syntaxin 5 Isoforms Syx5 and Syx5L have Distinct Effects on the Processing of β-amyloid Precursor Protein
- Studies on the Anti-allergic Mechanism of Glucocorticoids in Mice
- Anaplastic large-cell lymphoma (Ki-1 lymphoma) : ultrastructural and immunohistochemical studies
- Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes
- Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinase, collagens, and Ki67 antigen in pleural malignant mesothelioma : an immunohistochemical and electron microscopic study
- Increased exocytosis of secretory granules in contrast to reduced serum hormone levels in pituitary adenomas of humans and rats treated with dopamine agonist
- SPECIFIC SUPPRESSION OF ANTIGEN-ANTIBODY REACTIONS BY A DIALYSATE FROM DERMATOPHAGOIDES FARINAE
- IMMUNOGLOBULIN E ANTIBODY PRODUCTION AGAINST HOUSE DUST MITE, DERMATOPHAGOIDES FRARINAE, IN MICE
- Congenital mediastinal bronchogenic cyst with malignant transformation : An autopsy report
- Effect of CV-3988,a Specific Antagonist against Platelet Activating Factor, on Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- Thermal,Electrical and Magnetic Properties of the Ferromagnetic Dense Kondo System CeSi_x
- Expression of thrombomodulin in human aortic smooth muscle cells with special reference to atherosclerotic lesion types and age differences
- Radiation-induced Diffuse Brain Injury in the Neonatal Rat Model : Radiation-induced Apoptosis of Oligodendrocytes
- The Immunotoxicity of Triphenyltin Chloride in Mice
- The Effect of TRK-530 on Experimental Arthritis in Mice
- Primary hepatic leiomyosarcoma in a patient with hepatitis C virus-related liver cirrhosis
- Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
- ANALYSIS OF COMPRESSIVE FRACTURE OF CONCRETE BY VISCO-ELASTO-PLASTIC SUSPENSION ELEMENT METHOD USING DELAUNAY TRIANGULATION
- STUDY ON EFFECT OF VOLUME FRACTION OF COARSE AGGREGATE ON COMPRESSIVE FAILRE OF CONCRETE
- STUDY ON EFFECTS OF SIZE AND ARRANGEMENT OF COARSE AGGREGATE ON COMPRESSIVE FRACTURE BEHAVIOR OF CONCRETE
- EXPERIMENTAL STUDY ON PASSING BEHAVIOR OF FRESH CONCRETE BETWEEN STEEL BARS BY VISUALIZED MODEL CONCRETE
- Mitotic Specific Phosphorylation of Serine-1212 in Human DNA Topoisomerase IIα
- Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs
- Effect of a Non-Protein Fraction from an Extract of the Inflamed Skin of Rabbits Inoculated with Vaccinia Virus (Neurotropin) on Meth A-Induced Delayed Type Hypersensitivity
- The effects of TYB-2285 and its metabolites on eosinophil adhesion to tumor necrosis factor α-stimulated human umbilical vein endothelial cells
- EFFECT OF 1, 3-BIS (2-PHENYL-4-CHROMENON-5-YL)-2-OL ON EXPERIMENTAL ASTHMA IN GUINEA PIGS
- HISTAMINE RELEASE FROM RAT NEUTROPHILS AND MAST CELLS AS INDUCED BY IONOPHORE —A PHARMACOLOGICAL APPROACH—
- INHIBITION OF HOMOLOGOUS PASSIVE CUTANEOUS ANAPHYLAXIS (PCA) BY DISODIUM CROMOGLYCATE-RELATED COMPOUNDS
- PHARMACOLOGICAL STUDIES ON THE RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS DURING ANTI-IMMUNOGLOBULIN E ANTIBODY MEDIATED PASSIVE PERITONEAL ANAPHYLAXIS IN RATS
- EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
- Comparative Study of 1.5-Hour and 48-Hour Homologous Passive Cutaneous Anaphylaxis in the Mouse Ear
- The Effect of Substance P on the Antigen-Induced Bronchoconstriction in Guinea Pigs
- A COMPARATIVE STUDY OF THE ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM CROMOGLYCATE (DSCG)
- STUDIES ON THE MECHANISMS OF THE INHIBITORY EFFECT OF N-5 ON HISTAMINE RELEASE FROM RAT PERITONEAL EXUDATE CELLS
- THE SUSCEPTIBILITY OF EXPERIMENTAL GLOMERULONEPHRITIS IN SIX DIFFERENT STRAINS OF MICE
- ANTI-TUMOR EFFECT OF NEW 5-FLUOROURACIL DERIVATIVES AND THEIR INFLUENCES ON THE IMMUNE RESPONSE
- Antitumor Activity of Two Novel Low Immunosuppressive Fluoropyrimidines UK-21 and UK-25.
- Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-.BETA.-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-(1,5-a) pyridine (KC-404).
- Experimental glomerulonephritis in mice as a model for immunopharmacological studies.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). I. Anti-allergic action.
- Anti-allergic action of glucocorticoids in rats.
- Mechanisms of antiumor activity of aqueous extracts from chinese herbs: Their imunopharmacological properties.
- Active Principle of Swine Prostate Extract: II. Effect of a Peptide Isolated from Swine Prostate Extract on Rat Prostate.
- Potent inhibitory activity of HSR-6071, a new antiallergic agent, on Passive Cutaneous Anaphylaxis(PCA).
- Active Principle of Swine Prostate Extract:I. Isolation of Active Principle Activating Prostatic Acid Phosphatase and Its Effect on Testosterone Uptake of the Prostate in Castrated Rats.
- The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
- Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
- Inhibition of IgE antibody formation by n-pentyl .ALPHA.-L-sorbopyranoside.
- Mechanisms for Glucocorticoid Inhibition of Immediate Hypersensitivity Reactions in Rats.
- INHIBITION OF HYPERSENSITIVITY REACTIONS BY SOLUBLE DERIVATIVES OF BAICALEIN
- Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2). Regulation of Human IgE Response.
- Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (1). Regulation of Murine IgE Response.
- Effects of MKS-492 on Antigen-Induced Bronchoconstriction and Allergic Reaction in Guinea Pigs and Rats.
- Effect of N-5' on histamine release from rat peritoneal exudate cells induced by calcium ionophore and ATP.
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.
- Liver injury model in mice for immunopharmacological study.
- Effect of Three Novel K+ Channel Openers, Cromakalim, Pinacidil and Nicorandil on Allergic Reaction and Experimental Asthma.
- Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: meth A-induced delayed type hypersensitivity.
- Effect of OKY-046 and ONO-3708 on liver injury in mice.
- Immunopharmacological studies of sodium copper chlorphyllin (SCC).