Inhibitory Effect of AL-3264, a New Antiallergic Agent, on the Prausnitz-Kustner Reaction and Leukotriene Production in Monkeys

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To clarify the antiallergic effect and antiallergic mechanism of AL-3264 (<I>N</I>-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide) in monkeys, its effects on the Prausnitz-Küstner (PK) reaction, the histamine skin reaction and leukotriene production were examined. In contrast to ketotifen and mepyramine, AL-3264 inhibited the P-K reaction, which is mainly mediated by leukotriene and histamine, more clearly than the skin reaction evoked by histamine alone. AL-3264 also inhibited the leukotriene (LT) production in the broncho-alveolar cells, suggesting that the inhibition of LT production actually contributes to the antiallergic effect of AL-3264.
社団法人日本薬理学会の論文
1995-03-01