Effect of Surgical Removal on Survival and Quality of Life in Patients With Supratentorial Glioblastoma
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the extent of tumor resection and the progression-free survival, overall survival, and quality of life was evaluated retrospectively in 105 consecutive adult patients with supratentorial hemispheric glioblastoma not primarily involving the basal ganglia, thalamus, or hypothalamus. All patients underwent multidisciplinary treatment including tumor removal and postoperative adjuvant therapy in prospective randomized trials designed to test several chemotherapy regimens. Magnetic resonance imaging with contrast medium was used to determine the extent of tumor resection. Gross total resection (GTR) was performed in 35 patients (33%), partial resection (PR) in 57 (54%), and biopsy in 13 (12%). Univariate and multivariate analysis was performed to assess the prognostic relevance of the extent of resection. The Karnofsky performance status (KPS) improved from 78% to 83% in the GTR group. The difference was not statistically significant. There was no significant change in the PR (from 70% to 72%) and the biopsy groups (from 64% to 62%). Progression-free survival was significantly longer in the GTR group (median survival time [MST] 10.3 months) than in the PR (MST 5.2 months) and the biopsy groups (MST 3.6 months). The overall survival was significantly longer in the GTR group (MST 20 months) than in the PR (MST 14.2 months) and the biopsy groups (MST 8.3 months). The difference in survival between the PR and the biopsy groups was not statistically significant. GTR prolongs the survival of patients with glioblastoma compared to PR or biopsy.
- 日本脳神経外科学会の論文
- 2005-09-15
著者
-
Nakamura Hideo
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
-
Kai Yutaka
Department Of Neurosurgery University Of The Ryukyu Faculty Of Medicine
-
Kai Yutaka
Department Of Neurosurgery Kumamoto University Medical School
-
USHIO Yukitaka
Department of Neurosurgery, Kumamoto University Medical School
-
KOCHI Masato
Department of Neurosurgery, San-ai Hospital
-
Hamada Junichiro
金沢大学 医学系研究科脳病態制御学教室
-
Hamada Jun-ichiro
Department Of Neurosurgery Graduate School Of Medical Sciences Kanazawa University
-
Ushio Yukitaka
Department Of Neurosurgery Otemae Hospital
-
Ushio Yukitaka
Department Of Neuropsychiatry Surgery Osaka National Hospital
-
HAMADA Junichiro
Department of Neurosurgery, Kumamoto University Medical School
-
Hamada Junichiro
Department Of Histology And Neurobiology And Orthopedics Dokkyo University School Of Medicine
-
Hamada Jun-ichiro
Department Of Neurosurgery Kumamoto University Medical School
-
Kochi Masato
Department Of Neurosurgery San-ai Hospital
-
Hamada Junichiro
Department Of Neurosurgery Kumamoto University Medical School
-
Nakamura Hideo
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
-
Nakamura Hideo
Department Of Neurosurgery Graduate School Of Medical Sciences Kumamoto University
-
Nakamura Hideo
Department Of Cardiology Kyoto Prefectural Yosanoumi Hospital
-
Kai Yutaka
Department Of Neurosurgery Graduate School Of Medical Sciences Kumamoto University
-
Kochi Masato
Department Of Neurosurgery Kumamoto University Medical School
-
Kai Yutaka
Department Of Cerebrovascular Disease And Acute Coronary Syndrome Kumamoto University
関連論文
- Intracerebral hemorrhage secondary to ventriculoperitoneal shunt insertion - Four case reports
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- A Study on the Daily Physical Activity of Junior High School Students in Japan
- One-year Increment of Fat Mass and Lean Body Mass of Japanese School Children Using Bioelectrical Impedance
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- PE-394 p53 and SCO2 (Synthesis of Cytochrome c Oxidase 2) Augment the Progression of Diabetic Cardiomyopathy(PE066,Diabetes 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- Primary Malignant Lymphoma of the Brain in Children : Case Report
- Lymphocytic Adenohypophysitis Accompanying Occlusion of Bilateral Internal Carotid Arteries : Case Report
- Endoscopic Endonasal Transsphenoidal Approach Through the Bilateral Nostrils for Pituitary Adenomas
- Usefulness of Balloon Test Occlusion in the Diagnosis of Glossopharyngeal Neuralgia
- Endovascular Treatment of Ruptured Aneurysms Associated With Fenestrated Basilar Artery : Two Case Reports
- Comparative Clinical Study of the Anti-Emetic Effects of Oral Ramosetron and Injected Granisetron in Patients With Malignant Glioma Undergoing ACNU Chemotherapy
- Successful Clipping of a Distal Posterior Inferior Cerebellar Artery Aneurysm Located on the Anterior Surface of the Medulla Oblongata
- Radiation-induced Cerebrovasculopathy of the Distal Middle Cerebral Artery and Distal Posterior Cerebral Artery : Case Report
- Could Myocardial Staining with Computed Tomography Just after Direct PTCA for Acute Myocardial Infarction Predict the Size of Infarction? (X-ray/CT/MRI/DSA 8 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
- OE-232 p53 as a New Target of Cardiac Metabolism(Metabolism/Biochemistry/Energetics(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Cerebral Gumma Showing Spontaneous Regression on Magnetic Resonance Imaging Study : Case Report
- Epidemiology and Clinical Features of Asymptomatic Meningiomas
- Long-Term Survival after Successful Surgical Treatment of a Solitary Brain Metastasis
- Combination Chemotherapy with Cisplatin and Etoposide for Hematogenous Spinal Metastasis of Intracranial Germinoma : Case Report
- Effect of Radiation Therapy Against Intracranial Hemangiopericytoma
- Intracranial Cystic Hemangiopericytoma : Case Report
- Brain and Skull Metastases of Hepatic or Pancreatic Cancer : Report of Six Cases
- Intracranial Arterial Vasospasm Associated with Pituitary Apoplexy after Head Trauma : Case Report
- Choroidal Epithelial Cyst in the Cerebellopontine Angle associated with Trigeminal Neuralgia : Case Report
- Influence of Vasopressin Level on Osmotic Pressure and Sodium Concentration in Plasma and Cerebrospinal Fluid in Patients with Intracranial Lesions
- Trends in the incidence of primary intracranial tumors in Kumamoto, Japan
- B-11. Uptake of Bleomycin by Brain Tumors
- Increased Risk of Cerebral Thrombo-embolic Complication during Gradual Carotid Artery Occlusion Combined with Extra-and Intracranial Bypass Surgery in the Treatment of an Inaccessible Carotid Aneurysm
- Astroprotein (GFAP) Levels in Cerebrospinal Fluid of Stroke Patients
- Radioimmunoassay of Astroprotein (An Astrocyte-Specific Cerebroprotein) in Cerebrospinal Fluid and Its Clinical Significance
- Radioimmunoassay of Astroprotein (an Astrocyte-Specific Cerebroprotein) in Cerebrospinal Fluid From Patients with Glioma. A Preliminary Study
- A-47. Argon Laser Treatment of Brain Tumors
- B-21. Basic Experiment to Apply Laser Radiation for Treatment of Brain Tumors
- Unusual angiographic changes in an internal carotid artery pseudoaneurysm after infection in the deep neck space - Case report
- Effectiveness of Retrograde Perfusion of the Cerebral Vein for Attenuating Neuronal Injury After Transient Ischemia Following Reperfusion in the Rat Brain
- Pyogenic Upper Cervical Spinal Infection as a Cause of Sudden-onset Quadriplegia : Case Report
- Complete Response to Temozolomide Treatment in an Elderly Patient With Recurrent Primary Central Nervous System Lymphoma : Case Report
- Single Nucleotide Polymorphism 309 Affects Murin-Double-Minute 2 Protein Expression But Not Glioma Tumorigenesis
- Effect of Oral Colestimide on the Elimination of High-dose Methotrexate in Patients With Primary Central Nervous System Lymphoma : Two Case Reports
- -P145- ISCHEMIC MYOCARDIAL MITOCHONDRIAL FUNCTION AND STRUCTURE : INFLUENCE OF REGIONAL MYOCARDIAL BLOOD FLOW
- Malignant Trigeminal Schwannoma Associated with Xeroderma Pigmentosum : Case Report
- Heterogeneous Liquid-Phase Oxidation of Alcohols with Solid Oxidizing Reagents of Vanadium(V) Oxide and Chromium(VI) Oxide Supported on Zirconium(IV) Oxide
- Carotid and Vertebral Rete Mirabile in Man : Case Report
- Effect of Surgical Removal on Survival and Quality of Life in Patients With Supratentorial Glioblastoma
- Skull Metastasis From Clear Cell Chondrosarcoma
- The Post-ischemic Administration of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Prevents Delayed Neuronal Death in Gerbil H
- Heterogeneous Liquid Phase Oxidation of Alcohols with Zirconia-Supported Vanadium Oxide as Solid Oxidizing Reagent
- Occlusion of Internal Carotid Artery and Formation of Anterior Communicating Artery Aneurysm in Cervicocephalic Fibromuscular Dysplasia : Follow-up Case Report
- Cerebral Function after Aortic Surgery Using Retrograde Cerebral Perfusion : Report of Three Cases
- Rapid Regrowth of Solitary Subependymal Giant Cell Astrocytoma
- Dynamic Magnetic Resonance Appearance of the Vertebral Dissecting Aneurysm : Case Report
- Expression of Hqk Encoding a KH RNA Binding Protein Is Altered in Human Glioma
- Neurons Containing the Enzyme Nicotinamide Adenine Dinucleotide Phosphate (NADPH)-Diaphorase in Organotypic Static Slice Cultures of Rat Cerebral Cortices : Developmental Study
- Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas
- S-14. A Case of Delayed Radionecrosis Developed after Radiation Therapy for a Pituitary Tumor (Symosium:Non-Operatives Treauments for Brain Tumors)
- 101. Two Cases,One with Craniopharyngioma-like Syndrome and the Other with Precocious Puberty,Associated with Suprasellar Calcification after Tuberculous Meningitis (Proceedings of the XXVth Annual Meeting of the Japan Neurosurgical Society)
- Mobile robots on cylindrical surfaces
- Accessory Middle Cerebral Artery and Duplication of Middle Cerebral Artery : Terminology, Incidence, Vascular Etiology, and Developmental Significance
- Wrapping of Intracranial Aneurysms with Gauze Sponge
- Evidence for degeneration of mesostriatal dopaminergic neuron system in the zitter mutant rats.
- Anaplastic Astrocytoma with Extracranial Extension : Case Report
- PHYSICAL DEPENDENCE ON MEPROBAMATE AFTER REPEATED ORAL ADMINISTRATION IN RATS
- Interfacial Friction Factor for High-Pressure Steam/Water Stratified-Wavy Flow in Horizontal Pipe
- B-14 Environmental enrichment improves learning of the micrencephalic rat.
- Inhibitory Effect of AL-3264, a New Antiallergic Agent, on the Prausnitz-Kustner Reaction and Leukotriene Production in Monkeys
- Total Removal of Embryonal Carcinoma in the Pineal Region : Case Report and Review of the Literature
- Acute Subdural Hematoma After Lumboperitoneal Shunt Placement in Patients With Normal Pressure Hydrocephalus
- Fenestration of the Middle Cerebral Artery Associated with an Aneurysm : Case Report
- B301 APPLICATION OF RAIL TRANSMISSION TECHNOLOGY TO RAILWAY SIGNALS USING SPREAD SPECTRUM COMMUNICATION TECHNOLOGY
- EFFECT OF AD-1590,A NON-STEROIDAL ANTI-INFLAMMATORY AGENT WITH A POTENT ANTIPYRETIC ACTIVITY, ON IN VITRO PROSTAGLANDIN GENERATION IN RABBIT BRAIN
- Coil Embolization of an Aneurysm Located at the Trunk of the Persistent Primitive Trigeminal Artery : Case Report
- New Interpretation of the Transfer Coefficient in Electrochemistry
- Radical Scavenging Activities of Plant Food of Alkyl-oxy and Superoxide Radicals
- Large Encephalocele at the Anterior Fontanel : Case Report
- Friedel-Crafts Benzoylation of Alkylbenzenes with Benzoic Anhydride Catalyzed by Solid Superacids
- Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study
- Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
- Method for Constructing Decentralized Interlocking System Operating on Per-Track-Circuit Basis(Intemational Symposium on Speed-up and Service Technology for Railway and MAGLEV Systems)
- B302 Method for Constructing Autonomous Interlocking System Operating on Per-Track-Circuit Basis
- Epidemiological study of primary intracranial tumors : a regional survey in Kumamoto prefecture in southern Japan-20-year study
- The Post-ischemic Administration of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a Novel Calmodulin Antagonist, Prevents Delayed Neuronal Death in Gerbil Hi
- Type 1 Perimedullary Arteriovenous Fistula with Subarachnoid Hemorrhage : Utility of Contrast-enhanced 3D Gradient-echo Technique
- ^C MR Imaging of Methionine-rich Gliomas at 4.7T : A Pilot Study
- EARLY AND DELAYED PHASES OF HIND PAW EDEMA IN RATS
- Friedel-Crafts Acetylation, Propionylation, and Butyrylation of Toluene Catalyzed by Solid Superacids
- Huge Subdural Empyema with Unusual Presentation in Infant : Case Report
- Long-Term Outcome of Angioplasty or Stent Placement for Stenosis of the Cavernous or Petrous Portion of the Internal Carotid Artery
- Arterial Graft to Treat Ruptured Distal Middle Cerebral Artery Aneurysms in a Patient With Mucosa-Associated Lymphoid Tissue Lymphoma : Case Report
- Unusual Delayed Hydrocephalus After Bare Platinum Coil Embolization of an Unruptured Aneurysm : Case Report
- Site of analgesic action of zomepirac sodium, a potent non-narcotic analgesic in experimental animals.
- Performance Enhanced Efficient Precoder Design with Power Allocation for Multiuser MIMO Downlinks
- Hyperperfusion Syndrome After Stent Placement for Subclavian Artery Stenosis -Case Report-
- The Reaction of Acyl-substituted Sulfonium and Pyridinium Ylides with Diphenylthiirene Dioxide