Radioimmunoassay of Astroprotein (An Astrocyte-Specific Cerebroprotein) in Cerebrospinal Fluid and Its Clinical Significance

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Using radioimmunoassay,astroprotein (an astrocyte-specific cerebroprotein) in cerebrospinal fluid (CSF) from 81 cases with intracranial diseases(60 brain tumors and 21 miscellaneous lesions) and four cases with non-intracranial diseases was measured.Astroprotein in CSF of cases with non-intracranial disease was generally below 25 ng/ml.In contrast,10 of 17 cases(58.8%)with glioma,10 of 43 patients(23.3%)with brain tumors other than glioma and four of 21 patients(19.O%)with miscellaneous intracranial diseases (including seven cases of intracranial aneurysm,four of meningitis,three of hydrocephalus,three of epilepsy and two of Parkinsonism) showed elevated astroprotein (up to 500 ng/ml or more) in CSF.The cystic fluid in glioblastoma usually contained remarkably large amounts of astroprotein.
日本脳神経外科学会の論文