Effects of Bromocriptine on Staining Indices of Ki-67 and Proliferating Cell Nuclear Antigen, and Nucleolar Organizer Region Number in Pituitary Adenomas
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概要
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The effects of bromocriptine (CB-154) on the proliferative capacities of prolactinoma and somatotropinoma were investigated by immunocytochemical staining indices of proliferating cell nuclear antigen (PCNA) and Ki-67 (with MIB-1 antibody), and silver staining of nucleolar organizer region (NOR) number in histological sections. Patients with prolactinoma and somatotropinoma were divided into two groups: no preoperative treatment (control group), and treated with CB-154 for 2 weeks before adenomectomy (CB-154 group). The prolactinoma CB-154 group showed a significantly lower PCNA staining index (n = 6, 13.1 ± 2.0%) and Ki-67 staining index (n = 6, 0.2 ± 0.03%) than the control group (n = 4, 27.1 ± 2.1%; n = 8, 1.9 ± 0.5%; respectively) (p < 0.01). The somatotropinoma CB-154 group showed a significantly lower Ki-67 staining index (n = 5, 0.7 ± 0.07%) than the control group (n = 11, 1.2 ± 0.2%) (p < 0.05), but there was no significant difference in PCNA staining index (control: n = 5, 19.1 ± 2.8% vs. CB-154: n = 5, 20.2 ± 1.4%). However, variable intensities of PCNA staining between the cells were observed, resulting in an extraordinarily high staining index. NOR numbers did not vary significantly between the two prolactinoma groups (control: n = 4, 2.0 ± 0.3 vs. CB-154: n = 6, 1.7 ± 0.1) and two somatotropinoma groups (control: n = 5, 1.3 ± 0.1 vs. CB-154: n = 5, 1.4 ± 0.2). Ki-67 staining index with MIB-1 antibody in paraffin sections heated in a microwave oven is more reliable than PCNA staining index or NOR number for evaluating the proliferative capacities of pituitary adenomas. The immunocytochemical procedure with MIB-1 antibody was technically more feasible than that of Ki-67 in frozen section. The results suggest that CB-154 treatment has an anti-proliferative effect on prolactinomas and somatotropinomas.
- 日本脳神経外科学会の論文
- 1995-04-15
著者
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OHNISHI Takanori
Department of Neurosurgery, Osaka University Medical School
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HAYAKAWA Toru
Department of Neurosurgery, Osaka University Medical School
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SAITOH Youichi
Department of Neurosurgery, Osaka University Medical School
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ARITA Norio
Department of Biochemistry, Akita University School of Medicine
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Saitoh Youichi
大阪大学 医学系研究科脳神経外科学
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Saitoh Y
Dep. Of Neurosurgery Osaka Univ. Graduate School Of Medicine
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Hayakawa Toru
Department Of Biochemistry Akita University School Of Medicine
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EKRAMULLAH Shaikh
Department of Neurosurgery, Osaka University Medical School
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TAKI Takuyu
Department of Neurosurgery, Osaka University Medical School
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Taki Takuyu
Department Of Neurosurgery Osaka University Medical School
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Taki Takuyu
Department Of Neurosurgery Iseikai Hospital:department Of Neurosurgery Toyonaka City Hospital
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Ohnishi Takanori
Department Of Neurological Surgery Ehime University School Of Medicine
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Arita Norio
Department Of Neurosurgery Hyogo College Of Medicine
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Saitoh Youichi
Department Of Neurosurgery Department Of Medicine Osaka University Graduate School Of Medicine Osaka
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Ekramullah Shaikh
Department Of Neurosurgery Osaka University Medical School
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Saitoh Youichi
Department Of Neuromodulation And Neurosurgery Office For University-industry Collaboration Osaka University
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