Murine Model of Leptomeningeal Dissemination Using Human Medulloblastoma Cells
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概要
- 論文の詳細を見る
An experimental model of meningeal dissemination was developed by intracisternal inoculation of human medulloblastoma (ONS-76) cells into nude mice. All mice died within 65 days after inoculation of 1 × 10^7 tumor cells. The median survival time was 56 days. Clinical signs and histological findings were similar to those in medulloblastoma patients with meningeal dissemination. Immunohistochemical studies showed that ONS-76 cells in the subarachnoid space expressed major histocompatibility complex (MHC) class I antigens until 20 days after inoculation. After 30 days, expression of MHC class I antigens decreased and cells began to proliferate rapidly. Expression of MHC class I antigens on tumor cells may result in effective recognition by the host immune system.
- 日本脳神経外科学会の論文
- 1991-12-15
著者
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PARK Kae
Department of Neurosurgery, Kochi Medical School, Kochi University
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SHIMIZU Keiji
Department of Neurosurgery, Kochi Medical School, Kochi University
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HAYAKAWA Toru
Department of Neurosurgery, Osaka University Medical School
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Park Kae
Department Of Neurosurgery Osaka University Medical School
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Park Kae
Department Of Neurosurgery Kochi Medical School
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Shimizu Keiji
大阪大学 脳神経外科
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Shimizu K
Kumamoto Univ. School Of Medicine Kumamoto
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Hayakawa Toru
Department Of Biochemistry Akita University School Of Medicine
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MIYAO Yasuyoshi
Department of Neurosurgery, Osaka University Medical School
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MABUCHI Eiichiro
Department of Neurosurgery, Osaka University Medical School
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YAMADA Masanobu
Department of Neurosurgery, The Center for Adult Diseases
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TAMURA Kazuyoshi
Department of Neurosurgery, Osaka University Medical School
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MORIUCHI Shusuke
Department of Neurosurgery, Osaka University Medical School
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Yamada Masanobu
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Yamada Masanobu
Department Of Neurosurgry The Center For Adult Diseases
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Miyao Yasuyoshi
Department Of Neurosurgery Osaka University Medical School
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Miyao Yasuyoshi
Department Of Neurosurgery Osaka Koseinenkin Hospital Osaka
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Tamura Kazuyoshi
Department Of Neurosurgery Osaka University Medical School
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Tamura Kazuyoshi
Department Of Neurosurgery Hyogo College Of Medicine
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Moriuchi Shusuke
Department Of Neurosurgery Osaka University Medical School
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Mabuchi Eiichiro
Department Of Neurosurgery Osaka University Medical School
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Mabuchi Eiichiro
Department Of Neurosurgery Osaka Koseinenkin Hospital Osaka
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Shimizu Keiji
Department Of Neurosurgery Kochi Medical School
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Shimizu K
Research Unit For Cellular Immunotherapy And Research Unit For Therapeutic Model The Institute Of Ph
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Moriuchi Shusuke
Department Of Neurosurgery Osaka National Hospital
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