Comparative Clinical Study of the Anti-Emetic Effects of Oral Ramosetron and Injected Granisetron in Patients With Malignant Glioma Undergoing ACNU Chemotherapy
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概要
- 論文の詳細を見る
The effectiveness of ramosetron tablets and granisetron injection was compared for reducing the frequency of nausea, vomiting, and anorexia in patients with malignant glioma undergoing ACNU chemotherapy. Patients with malignant glioma to be treated with ACNU chemotherapy were randomly assigned to receive oral ramosetron (20 patients) or intravenous granisetron (19 patients) prior to ACNU injection. Gastrointestinal toxicity within 48 hours of ACNU injection was compared to that in patients who had received ACNU chemotherapy with dopamine D2 receptor-blocker as a historical control group. Within 24 hours of the administration of ACNU, 15 of the 20 patients treated with ramosetron and 16 of the 19 treated with granisetron were nausea-free, and 14 of the former and 14 of the latter regained their normal appetite. There was no significant difference in the anti-emetic effects. Ten of the 17 controls experienced no vomiting within 6 hours of the injection of ACNU, five were nausea-free within 24 hours, and two retained their normal appetite within 24 hours. Oral ramosetron has the same anti-anorectic and anti-emetic effects as intravenous granisetron. Ramosetron tablets are less expensive and are easy to take, so should be on the list of first-choice anti-emetic drugs for patients treated with ACNU chemotherapy.
- 日本脳神経外科学会の論文
- 2005-06-15
著者
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HAMADA Jun-ichiro
Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University
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Nakamura Hideo
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Kai Yutaka
Department Of Neurosurgery University Of The Ryukyu Faculty Of Medicine
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Kai Yutaka
Department Of Neurosurgery Kumamoto University Medical School
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KURATSU Jun-ichi
Department of Neurosurgery, Kumamoto University Medical School
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YANO Shigetoshi
Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Grad
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MAKINO Keishi
Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Grad
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MORIOKA Motohiro
Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Grad
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KOCHI Masato
Department of Neurosurgery, San-ai Hospital
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Hamada Junichiro
金沢大学 医学系研究科脳病態制御学教室
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Hamada Jun-ichiro
Department Of Neurosurgery Graduate School Of Medical Sciences Kanazawa University
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Hamada Jun-ichiro
Department Of Neurosurgery Graduate School Of Medical Science Kanazawa University
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Kuratsu Jun-ichi
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Makino Keishi
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Kuratsu Jun-ichi
Department Of Neurosurgery Graduate School Of Medical Sciences Kumamoto University
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Kuratsu Jun-ichi
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Kai Yutaka
Department Of Neurosurgery Kumamoto University School Of Medicine
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Kuratsu Jun-ichi
Department Of Neurosurgery Shimonoseki Kosei Hospital
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Hamada Jun-ichiro
Department Of Neurosurgery Kumamoto University Medical School
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Yano Shigetoshi
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Kochi Masato
Department Of Neurosurgery San-ai Hospital
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Hamada Junichiro
Department Of Neurosurgery Kumamoto University Medical School
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Yano Shigetoshi
Department Of Neurosurgery Kumamoto University School Of Medicine
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Hamada Jun-ichiro
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Morioka Motohiro
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Nakamura Hideo
Department Of Cardiovascular Medicine Kyoto Prefectural University Of Medicine
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Yano Shigetoshi
Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University
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Shigematsu Yoshinori
Department Of Radiology Kumamoto University School Of Medicine
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Nakamura Hideo
Department Of Neurosurgery Graduate School Of Medical Sciences Kumamoto University
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Nakamura Hideo
Department Of Cardiology Kyoto Prefectural Yosanoumi Hospital
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Kai Yutaka
Department Of Neurosurgery Graduate School Of Medical Sciences Kumamoto University
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Kuratsu Jun-ichi
Department Of Neurosurgery Faculty Of Medical And Pharmaceutical Sciences Kumamoto University Gradua
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Kochi Masato
Department Of Neurosurgery Kumamoto University Medical School
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Kai Yutaka
Department Of Cerebrovascular Disease And Acute Coronary Syndrome Kumamoto University
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