MECHANISM OF METABOLIC ACTIVATION OF CARCINOGENIC 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE
スポンサーリンク
概要
著者
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MORI Yukio
Gifu Pharmaceutical University
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Mori Yukio
Institute Of Biological Pharmacy Gifu Pharmaceutical University
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Morishita Y
First Department Of Pathology Gifu University School Of Medicine
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Koda A
Gifu Pharmaceutical Univ. Gifu Jpn
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Toyoshi Kazumi
Department Of Pathology Gifu University School Of Medicine
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KAWADA Kenji
Gifu College of Medical Technology
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TOYOSHI KAZUMI
Gifu Pharmaceutical University
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Tamura Kazutoshi
Department Of Oncological Pathology Cancer Center Nara Medical University
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HORI TOSHIRO
Gifu College of Pharmacy
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NIWA TOSHIRO
Gifu College of Pharmacy
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NAGAI HIROICHI
Gifu College of Pharmacy
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KODA AKIHIDE
Gifu College of Pharmacy
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OJIMA AKITSUGU
Gifu University School of Medicine
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Kinjo Tatsuya
Tumor Pathology University Of Ryukyus Faculty Of Medicine
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Kinjo Tatsuya
Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima
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Yoshimoto Masatoshi
Surgical Center Nara Medical University Hospital
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Kawamori Toshihiko
Department Of Pathology Gifu University School Of Medicine
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Toyoshi Kazumi
Gifu Collgege Of Pharmacy
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Yoshimoto Masatoshi
Gifu Pharmaceutical University
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TOYOSHI Kazumi
Gifu College of Pharmacy
関連論文
- Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
- Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1, 2-dimethylhydrazine dihydrochloride
- Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
- Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Absence of mutagenic action of 5β-cholan-24-oic acid derivatives in the bacterial fluctuation and standard Ames tests.
- Common Duct Carcinoma and Obstruction in Female Hamsters Treated with N-Nitrosobis(2-oxopropyl)amine and/or Cholecystectomy.
- Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon
- Immunopharmacological Studies of Unsei-In(Wen-Qing-Yin), a Chinese Blended Medicine. : Examination of Most Effective One of Chinese Herbs Composed of Unsei-In on Type IV Hypersensitivity Reaction.
- Genetic alterations in a patient with Turcot's syndrome
- CARCINOGENICITY EXAMINATION OF 1-NITROPYRENE OXIDES AND RELATED CHEMICALS : LACK OF THEIR TUMORIGENIC EFFECTS IN A NEWBORN MICE ASSAY
- Increased Telomerase Activities in Human Pancreatic Duct Adenocarcinomas
- Mutagenic activation of N-nitrosobis(2-oxopropyl)amine by pancreatic juice and assessment of its ductal tumorigenicity following intraductal administration in dogs.
- Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
- N-Benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in hort-term genotoxicity assays.
- Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
- Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
- Effect of Cigarette Smoke on the Mutagenic Activation of Environmental Carcinogens by Rodent Liver.
- High Susceptibility of p53(+/-)Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele.
- Telomerase Activity Correlates with Growth of Transplantable Osteosarcomas in Rats Treated with cis-Diammine Dichloroplatinum or the Angiogenesis Inhibitor AGM-1470
- Comutagenic Effect of Bile Acids with 2-Aminoanthracene, 1,2-Dimethylhydrazine and Pancreas-carcinogenic N-Nitroso Compounds.
- Enhancement of N-nitrosodiethylamine-Initiated Hepatocarcinogenesis Caused by a Colchicine-induced Cell Cycle Disturbance in Partially Hepatectomized Rats.
- Lack of significant tumor induction by endogeneously formed N-nitrosobis(2-hydroxypropyl)amine in rats fed tris(2-hydroxypropyl)-amine and sodium nitrite.
- Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
- A New cytochrome P450 inducer for Ames test.
- Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
- Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
- Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
- Activation of Carcinogenic N-Nitrosopropylamines to Mutagens by Lung and Pancreas S9 Fractions from Various Animal Species and Man.
- A Comparative Study of the Mutagenic Activation of N-Nitrosopropylamines by Various Animal Species and Man : Evidence for a Cytochrome P-450 Dependent Reaction.
- Mutagenic Activation of Carcinogenic N-Nitrosopropylamines by Liver S9 Fractions from Mice, Rats, and Hamsters : Evidence for a Cytochrome P-450 Dependent Reaction.
- Role of Alkaline Phosphatase in Phosphate Uptake into Brush Border Membrane Vesicles from Human Intestinal Mucosa.
- In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
- HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
- CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO COMPOUNDS
- Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (II) : Metabolism, Absorption to Inflammed Site after Single Application, and Absorption, Distribution and Excretion after Consecutive Applicati
- Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (I) : Absorption, Distribution and Excretion in Rats and Absorption and Excretion in Guinea Pigs.
- Species Differences in the Metabolism of Suprofen in Laboratory Animals and Man.
- INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
- COMPARISON OF FLUOROMETRIC ASSAY AND GAS CHROMATOGRAPHY-MASS SPECTROMETRIC METHOD FOR DETERMINATION OF TRYPTOPHAN AND SEROTONINE
- Application of Radioisotope Tracer Techniques to Analytical Gas Chromatography : Determination of Gas Chromatographic Peak Yield.
- Vascular Changes in Primary and Transplantable Pancreatic Adenocarcinomas Induced by Propylnitrosamines.
- Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
- Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine(BHP) in rats administered bis(2-hydroxypropyl)-amine(BHPA) and sodium nitrite(SN).
- Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver.
- Carcinogenic Potency of N-nitrosomethyl(2-hydroxypropyl)amine and Other Metabolic Relatives of N-Nitrosobis(2-hydroxypropyl)amine by Single Intraperitoneal Injection on the Lung of Rats.
- Mutagenesis of Isopropanolamines and Ethanolamines after Reaction with Sodium Nitrite.
- METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS
- Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
- Inhibitory Effect of Organic Solvents on the Mutagenicity of N-Nitrosodialkylamines in Salmonella.
- Mutagenic Activation of Carciuogenic N-Nitrosopropylamines by Rat Liver : Evidence for a Cytochrome P-450 Dependent Reaction.
- AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
- Irreversible Cytotoxic Effect of a Novel Lowly Immunosuppressive Antitumor Fluorouridine Derivative, UK-21.
- Irreversible Cytotoxic Effect of a Novel Low Immunosuppressive Antitumor Fluorouridir Derivative, UK-21
- Suppressive effects of tranilast on pulmonary fibrosis and activation of alveolar macrophages in mice treated with bleomycin : role of alveolar macrophages in the fibrosis.
- Principle of the bark of Phellodendron amurense to suppress the cellular immune response : effect of phellodendrine on cellular and humoral immune responses.
- Principle of the bark of Phellodendron amurense to suppress the cellular immune response.
- Mechanism for macrophage activation against Corynebacterium parvum : participation of T cells and its lymphokines.
- Novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21 : antitumor activity and effect on humoral immune response in mice.
- The Effect of a Novel Thromboxane A_2 (TXA_2) Receptor Angagonist (S-1452) on the Antigen-Induced Bronchoconstriction and Airway Hyperresponsiveness in Guinea Pigs.
- Effects of NZ-107 on Airway Inflammation and Cell Activation in Guinea-Pigs.
- Novel Low Immunosuppressive Derivatives of the Antitumor Drug Fluoropyrimidine, UK-21 and UK-25 : Effect on Delayed Type Hypersensitivity and Tumor Immunity.
- Hepatocarcinogenic Activities of Hydorxymethyl Derivatives of 4-(N, N-Dimethylamino)azobenzene in ACI/N Rats.
- IMMUNOPHARMACOLOGICAL STUDIES ON MYDOCALM AND RELATED COMPOUNDS AS AN ANTAGONIST OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A)
- Mutagenicity of N-Nitrosodiethanolamine in the Salmonella/Microsome Test.
- MECHANISM OF METABOLIC ACTIVATION OF CARCINOGENIC 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE
- 4-Hydroxyaminoquinoline 1-0xide Metabolism and DNA Adducts in the Early Stage of Tumorigenesis in Rats : Comparison of Target Organ Pancreas with Non-Target Organ Liver.
- Mutagenic Activation of Selected Aminoazo Compounds by Rat Liver: Evidence for a Cytochrome P-448 Dependent Reaction
- CARCINOGENIC AZO DYES. IX. DETECTION OF NEW METABOLITES OF 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE IN RAT BILE
- The effect of Gomisin A on immunologic liver injury in mice.
- Antitumor Activity of Two Novel Low Immunosuppresive Fluoropyrimidines UK-21 and UK-25.
- Effect of Immunostimulants and Antitumor Agents on Tumor Necrosis Factor (TNF) Production.
- Antitumor activity of some kinds of crude drugs.
- Effect of a non-protein fraction from an extract of the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin) on Meth A-induced delayed type hypersensitivity.
- Solid phase enzyme-linked immunosorbent assay(ELISA) for anti-sheep erythrocyte antibody in mouse serum.
- Immunological mechanisms of antitumor activity of some kinds of crude drugs on tumor necrosis factor production
- Antitumor principle of Artemisiae capillaries Herba and its related compound.
- Mechanisms of antitumor activity of aqueous extracts from chinese herbs : Their immunopharmacological properties.
- Immunological Mechanisms of Antitumor Activity of Some Kinds of Chinese Herbs : Meth A-Induced Delayed Type Hypersensitivity.
- INVOLVEMENT OF MICROSOMAL CYTOCHROME P-450 IN THE MUTAGENIC ACTIVATION OF 9 CARCINOGENIC N-NITROSOPROPYLAMINE DERIVATIVES BY LIVER S9 FROM 5 ANIMAL SPECIES AND MAN
- Effect of a Newly Synthesized Leukotriene Antagonist, (E)-2,2-Diethyl-3'-2-2-(4-Isopropyl)Thiazolyl Ethenyl Succinanilic Acid (MCI-826), on Immunological Liver Injury and Nephritis in Mice.
- Effects of a Newly Synthesized Leukotriene Antagonist, NZ-107,on Immediate-Type Hypersensitivity Reaction in Rats and Guinea-Pigs.
- Anti-allergic action of gomisin A (TJN-101).
- Suppressive Effects of Tranilast on Pulmonary Fibrosis and Activation of Alveolar Macrophages in Mice Treated with Bleomycin: Role of Alveolar Macrophages in the Fibrosis
- Effect of Suplatast Tosilate (IPD-1151T) on Types I-IV Allergic Reactions.
- Effects of Suplatast Tosilate (IPD-1151T) on Antibody Formation in Mice.
- Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs
- Effect of OKX-046 and ONO-3708 on liver injury in mice.
- The role of thromboxane A_2(TxA_2)in liver injury in mice.
- Role of peptide-leukotrienes in liver injury in mice.
- Inhibition of Antigen-Induced Contracticon of Guinea Pig Isolated Tracheal Muscle with 2-n-Butyl-3-Dimethylamino-5,6-Methylenedioxy Indene (MDI-A), Indane (MDI-B) and 8-(Diethylamino)octyl-3,4,5-Trimethoxy Benzoate Hydrochloride
- Novel Derivatives of 5-Fluorouridine and 5-Fluorouracil Having Potent Antitumor and Lower Immunosuppressive Activities.
- The role of thromboxane A_2 in experimental liver injury in mice.
- The Effect of Three Novel Thromboxane A_2 Receptor Antagonists (S-1452,AA-2414 and ONO-3708) on the Increase in Pulmonary Pressure Caused by Forssman Anaphylaxis in Guinea-Pigs.
- The Effect of Substance P on the Antigen-Induced Bronchoconstriction in Guinea Pigs
- Change in the Activity of the Cyclic AMP-Dependent Protein Kinase in Antigen-Stimulated Sensitized Mast Cells and Effect of Drugs Inhibiting Allergic Mediator Release.
- Differences Among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine
- Effect of (.+-.)-2-(p-(2-thenoyl)phenyl) propionic acid (suprofen) on experimental allergic reactions.