Mutagenic Activation of Selected Aminoazo Compounds by Rat Liver: Evidence for a Cytochrome P-448 Dependent Reaction

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概要

• 論文の詳細を見る
• 日本癌学会の論文

著者

• MORI Yukio

  Gifu Pharmaceutical University

• Morishita Y

  First Department Of Pathology Gifu University School Of Medicine

• Toyoshi Kazumi

  Department Of Pathology Gifu University School Of Medicine

• Mori Yukio

  Laboratory Of Radiochemistry Gifu Pharmaceutical University

• Tamura Kazutoshi

  Department Of Oncological Pathology Cancer Center Nara Medical University

• Yoshimoto Masatoshi

  Surgical Center Nara Medical University Hospital

• Toyoshi Kazumi

  Gifu Collgege Of Pharmacy

• Yoshimoto Masatoshi

  Gifu Pharmaceutical University

関連論文

• Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
• Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1, 2-dimethylhydrazine dihydrochloride
• Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
• Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
• Carcinoid tumor in the female urethral orifice : Rare case report and a review of the literature
• Induction of Apoptosis by Sulindac in Azoxymethane-induced Possible Colonic Premaligmant Lesions in Rats
• Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
• Absence of mutagenic action of 5β-cholan-24-oic acid derivatives in the bacterial fluctuation and standard Ames tests.
• Common Duct Carcinoma and Obstruction in Female Hamsters Treated with N-Nitrosobis(2-oxopropyl)amine and/or Cholecystectomy.
• Dietary Prevention of Azoxymethane-Induced Colon Carcinogenesis with Rice-Germ in F344 Rats.
• Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon
• Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
• Inhibitory Effect of Chlorophyllin on Diethylnitrosamine and Phenobarbital-induced Hepatocarcinogenesis in Male F344 Rats
• Chemopreventive Effects of Taurine on Diethylnitrosamine and Phenobarbitalinduced Hepatocarcinogenesis in Male F344 Rats
• Chemoprevention of 4-Nitroquinoline 1-Oxide-Induced Oral Carcinogenesis by Dietary Protocatechuic Acid During Initiation and Postinitiation Phases.
• A Xanthine Oxiedase Inhibitor 1'-Acetoxychavicol Acetate Inhibits Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats.
• Chemopreventive Effect of a Xanthine Oxidase Inhibitor, l'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis.
• Inhibitory effect of dietary monoglucosylceramide 1-O-β-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats
• Genetic alterations in a patient with Turcot's syndrome
• CARCINOGENICITY EXAMINATION OF 1-NITROPYRENE OXIDES AND RELATED CHEMICALS : LACK OF THEIR TUMORIGENIC EFFECTS IN A NEWBORN MICE ASSAY
• Increased Telomerase Activities in Human Pancreatic Duct Adenocarcinomas
• Chemopreventive Effects of Dietary D, L-α-Difluoromethylornithine, an Ornithine Decarboxylase Inhibitor, on Initiation and Postinitiation Stages of Diethylnitrosamine-induced Rat Hepatocarcinogenesis.
• Chemoprevention of Oral Carcinogenesis by DL-α-Difluorometylornithine, an Orinithine Decarboxylase Inhibitor : Dose-dependent Reduction 4-Nitroquinoline 1-Oxide-induced Tongu Neoplasms in Rats.
• Effects of High Amylose Maize Starch and Clostridium butyricum on Metabolism in Colonic Microbiota and Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon
• Genetic Variation in 16S-23S rDNA Internal Transcribed Spacer Regions and the Possible Use of This Genetic Variation for Molecular Diagnosis of Bacteroides Species
• Protective Effects of a Culture Supernatant of Lactobacillus acidophilus and Antioxidants on Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug
• Culture Supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis Repress Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug by Suppressing Unbalanced Growth of Aerobic Bacteria and Lipid Peroxidation
• Role of Intestinal Bacteria in Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug
• Purification and Characterization of a Fibrinogen-Degrading Protease in Bacteroides fragilis Strain YCH46
• Rapid Species Identification and Partial Strain Differentiation of Clostridium butyricum by PCR Using 16S-23S rDNA Intergenic Spacer Regions
• Suppression of Occurrence and Advancement of β-Catenin-accumulated Crypts, Possible Premalignant Lesions of Colon Cancer, by Selective Cyclooxygenase-2 Inhibitor, Celecoxib
• Mutagenic activation of N-nitrosobis(2-oxopropyl)amine by pancreatic juice and assessment of its ductal tumorigenicity following intraductal administration in dogs.
• Inhibitory Effects of Dietary Protocatechuic Acid and Costunolide on 7,12-Dimethylbenz[a ]anthracene-induced Hamster Cheek Pouch Carcinogenesis
• Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
• Suppression of Azoxymethane-induced Rat Colon Carcinogenesis by Dietary Administration of Naturally Occurring Xanthophylls Astaxanthin and Canthaxanthin During the Postinitiation Phase.
• Chemoprevention of Urinary Bladder Carcinogenesis by the Natural Phenolic Compound Protocatechuic Acid in Rats.
• Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Dietary Feeding of S-Methyl Methane Thiosulfonatein Male F344 Rats.
• Suppression of Azoxymethane-induced Colonic Aberrant Crypt Foci by Dietary Exposure to a Novel Synthesized Retinoidal Butenolide, 5-Hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone, in Rats.
• Modifying Effects of Naturally Occurring Products on the Development of Colonic Aberrant Crypt Foci Induced by Azoxymethane in F344 Rats.
• Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
• Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
• N-Benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in hort-term genotoxicity assays.
• Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
• Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
• Effect of Cigarette Smoke on the Mutagenic Activation of Environmental Carcinogens by Rodent Liver.
• High Susceptibility of p53(+/-)Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele.
• Telomerase Activity Correlates with Growth of Transplantable Osteosarcomas in Rats Treated with cis-Diammine Dichloroplatinum or the Angiogenesis Inhibitor AGM-1470
• Comutagenic Effect of Bile Acids with 2-Aminoanthracene, 1,2-Dimethylhydrazine and Pancreas-carcinogenic N-Nitroso Compounds.
• Enhancement of N-nitrosodiethylamine-Initiated Hepatocarcinogenesis Caused by a Colchicine-induced Cell Cycle Disturbance in Partially Hepatectomized Rats.
• Lack of significant tumor induction by endogeneously formed N-nitrosobis(2-hydroxypropyl)amine in rats fed tris(2-hydroxypropyl)-amine and sodium nitrite.
• Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
• A New cytochrome P450 inducer for Ames test.
• Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
• Antimutagenicity of Murdannia Loriformis in the Salmonella mutation assay and its inhibitory effects on azoxmethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
• Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
• Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneo-plastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver
• Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
• Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
• Activation of Carcinogenic N-Nitrosopropylamines to Mutagens by Lung and Pancreas S9 Fractions from Various Animal Species and Man.
• A Comparative Study of the Mutagenic Activation of N-Nitrosopropylamines by Various Animal Species and Man : Evidence for a Cytochrome P-450 Dependent Reaction.
• Mutagenic Activation of Carcinogenic N-Nitrosopropylamines by Liver S9 Fractions from Mice, Rats, and Hamsters : Evidence for a Cytochrome P-450 Dependent Reaction.
• Role of Alkaline Phosphatase in Phosphate Uptake into Brush Border Membrane Vesicles from Human Intestinal Mucosa.
• In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
• HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
• CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO COMPOUNDS
• Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (II) : Metabolism, Absorption to Inflammed Site after Single Application, and Absorption, Distribution and Excretion after Consecutive Applicati
• Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (I) : Absorption, Distribution and Excretion in Rats and Absorption and Excretion in Guinea Pigs.
• Species Differences in the Metabolism of Suprofen in Laboratory Animals and Man.
• INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
• COMPARISON OF FLUOROMETRIC ASSAY AND GAS CHROMATOGRAPHY-MASS SPECTROMETRIC METHOD FOR DETERMINATION OF TRYPTOPHAN AND SEROTONINE
• Application of Radioisotope Tracer Techniques to Analytical Gas Chromatography : Determination of Gas Chromatographic Peak Yield.
• Vascular Changes in Primary and Transplantable Pancreatic Adenocarcinomas Induced by Propylnitrosamines.
• Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
• Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine(BHP) in rats administered bis(2-hydroxypropyl)-amine(BHPA) and sodium nitrite(SN).
• Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver.
• Carcinogenic Potency of N-nitrosomethyl(2-hydroxypropyl)amine and Other Metabolic Relatives of N-Nitrosobis(2-hydroxypropyl)amine by Single Intraperitoneal Injection on the Lung of Rats.
• Mutagenesis of Isopropanolamines and Ethanolamines after Reaction with Sodium Nitrite.
• METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS
• Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
• Inhibitory Effect of Organic Solvents on the Mutagenicity of N-Nitrosodialkylamines in Salmonella.
• Mutagenic Activation of Carciuogenic N-Nitrosopropylamines by Rat Liver : Evidence for a Cytochrome P-450 Dependent Reaction.
• AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
• Hepatocarcinogenic Activities of Hydorxymethyl Derivatives of 4-(N, N-Dimethylamino)azobenzene in ACI/N Rats.
• Mutagenicity of N-Nitrosodiethanolamine in the Salmonella/Microsome Test.
• MECHANISM OF METABOLIC ACTIVATION OF CARCINOGENIC 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE
• 4-Hydroxyaminoquinoline 1-0xide Metabolism and DNA Adducts in the Early Stage of Tumorigenesis in Rats : Comparison of Target Organ Pancreas with Non-Target Organ Liver.
• Mutagenic Activation of Selected Aminoazo Compounds by Rat Liver: Evidence for a Cytochrome P-448 Dependent Reaction
• CARCINOGENIC AZO DYES. IX. DETECTION OF NEW METABOLITES OF 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE IN RAT BILE
• INVOLVEMENT OF MICROSOMAL CYTOCHROME P-450 IN THE MUTAGENIC ACTIVATION OF 9 CARCINOGENIC N-NITROSOPROPYLAMINE DERIVATIVES BY LIVER S9 FROM 5 ANIMAL SPECIES AND MAN
• Differences Among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine
• Effect of (.+-.)-2-(p-(2-thenoyl)phenyl) propionic acid (suprofen) on experimental allergic reactions.

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