<Abstract of annual report>Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (II) : Metabolism, Absorption to Inflammed Site after Single Application, and Absorption, Distribution and Excretion after Consecutive Applicati
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概要
著者
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MORI Yukio
Institute of Biological Pharmacy, Gifu Pharmaceutical University
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MORI Yukio
Gifu Pharmaceutical University
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Morishita Y
Institute Of Biological Pharmacy Gifu Pharmaceutical University
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Mori Yukio
Institute Of Biological Pharmacy Gifu Pharmaceutical University
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Yoshimoto Masatoshi
Department Of Oncological Pathology Cancer Center Nara Medical University
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Yoshimoto M
Department Of Oncological Pathology Cancer Center Nara Medical University
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Mori Yukio
岐阜薬科大学 生物薬学研究所
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Yoshimoto Masatoshi
Surgical Center Nara Medical University Hospital
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Mizumoto Yasushi
Surgical Center Nara Medical University Hospital
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Yoshimoto Masatoshi
Gifu Pharmaceutical University
関連論文
- Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Absence of mutagenic action of 5β-cholan-24-oic acid derivatives in the bacterial fluctuation and standard Ames tests.
- Common Duct Carcinoma and Obstruction in Female Hamsters Treated with N-Nitrosobis(2-oxopropyl)amine and/or Cholecystectomy.
- Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon
- Genetic alterations in a patient with Turcot's syndrome
- CARCINOGENICITY EXAMINATION OF 1-NITROPYRENE OXIDES AND RELATED CHEMICALS : LACK OF THEIR TUMORIGENIC EFFECTS IN A NEWBORN MICE ASSAY
- Increased Telomerase Activities in Human Pancreatic Duct Adenocarcinomas
- Mutagenic activation of N-nitrosobis(2-oxopropyl)amine by pancreatic juice and assessment of its ductal tumorigenicity following intraductal administration in dogs.
- Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
- N-Benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in hort-term genotoxicity assays.
- Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
- Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
- Effect of Cigarette Smoke on the Mutagenic Activation of Environmental Carcinogens by Rodent Liver.
- High Susceptibility of p53(+/-)Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele.
- Telomerase Activity Correlates with Growth of Transplantable Osteosarcomas in Rats Treated with cis-Diammine Dichloroplatinum or the Angiogenesis Inhibitor AGM-1470
- Comutagenic Effect of Bile Acids with 2-Aminoanthracene, 1,2-Dimethylhydrazine and Pancreas-carcinogenic N-Nitroso Compounds.
- Enhancement of N-nitrosodiethylamine-Initiated Hepatocarcinogenesis Caused by a Colchicine-induced Cell Cycle Disturbance in Partially Hepatectomized Rats.
- Lack of significant tumor induction by endogeneously formed N-nitrosobis(2-hydroxypropyl)amine in rats fed tris(2-hydroxypropyl)-amine and sodium nitrite.
- Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
- A New cytochrome P450 inducer for Ames test.
- Expression of heterodimeric (placental-intestinal) hybrid alkaline phosphatase in KB cells.
- Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
- Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
- Activation of Carcinogenic N-Nitrosopropylamines to Mutagens by Lung and Pancreas S9 Fractions from Various Animal Species and Man.
- A Comparative Study of the Mutagenic Activation of N-Nitrosopropylamines by Various Animal Species and Man : Evidence for a Cytochrome P-450 Dependent Reaction.
- Mutagenic Activation of Carcinogenic N-Nitrosopropylamines by Liver S9 Fractions from Mice, Rats, and Hamsters : Evidence for a Cytochrome P-450 Dependent Reaction.
- Role of Alkaline Phosphatase in Phosphate Uptake into Brush Border Membrane Vesicles from Human Intestinal Mucosa.
- In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
- HUMAN AND RAT LIVER-CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF AMINO ACID PYROLYSATES
- CYTOSOLIC COMPONENTS INVOLVED IN MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO COMPOUNDS
- Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (II) : Metabolism, Absorption to Inflammed Site after Single Application, and Absorption, Distribution and Excretion after Consecutive Applicati
- Studies on the Disposition of Suprofen Ointment After Occlusive Topical Application (I) : Absorption, Distribution and Excretion in Rats and Absorption and Excretion in Guinea Pigs.
- Species Differences in the Metabolism of Suprofen in Laboratory Animals and Man.
- INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
- COMPARISON OF FLUOROMETRIC ASSAY AND GAS CHROMATOGRAPHY-MASS SPECTROMETRIC METHOD FOR DETERMINATION OF TRYPTOPHAN AND SEROTONINE
- Application of Radioisotope Tracer Techniques to Analytical Gas Chromatography : Determination of Gas Chromatographic Peak Yield.
- Vascular Changes in Primary and Transplantable Pancreatic Adenocarcinomas Induced by Propylnitrosamines.
- Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
- Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine(BHP) in rats administered bis(2-hydroxypropyl)-amine(BHPA) and sodium nitrite(SN).
- Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver.
- Carcinogenic Potency of N-nitrosomethyl(2-hydroxypropyl)amine and Other Metabolic Relatives of N-Nitrosobis(2-hydroxypropyl)amine by Single Intraperitoneal Injection on the Lung of Rats.
- Mutagenesis of Isopropanolamines and Ethanolamines after Reaction with Sodium Nitrite.
- METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS
- Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
- Inhibitory Effect of Organic Solvents on the Mutagenicity of N-Nitrosodialkylamines in Salmonella.
- Mutagenic Activation of Carciuogenic N-Nitrosopropylamines by Rat Liver : Evidence for a Cytochrome P-450 Dependent Reaction.
- AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
- Hepatocarcinogenic Activities of Hydorxymethyl Derivatives of 4-(N, N-Dimethylamino)azobenzene in ACI/N Rats.
- Mutagenicity of N-Nitrosodiethanolamine in the Salmonella/Microsome Test.
- MECHANISM OF METABOLIC ACTIVATION OF CARCINOGENIC 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE
- 4-Hydroxyaminoquinoline 1-0xide Metabolism and DNA Adducts in the Early Stage of Tumorigenesis in Rats : Comparison of Target Organ Pancreas with Non-Target Organ Liver.
- Mutagenic Activation of Selected Aminoazo Compounds by Rat Liver: Evidence for a Cytochrome P-448 Dependent Reaction
- CARCINOGENIC AZO DYES. IX. DETECTION OF NEW METABOLITES OF 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE IN RAT BILE
- INVOLVEMENT OF MICROSOMAL CYTOCHROME P-450 IN THE MUTAGENIC ACTIVATION OF 9 CARCINOGENIC N-NITROSOPROPYLAMINE DERIVATIVES BY LIVER S9 FROM 5 ANIMAL SPECIES AND MAN
- Differences Among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine
- Effect of (.+-.)-2-(p-(2-thenoyl)phenyl) propionic acid (suprofen) on experimental allergic reactions.