CARCINOGENIC AZO DYES. IX. DETECTION OF NEW METABOLITES OF 3'-METHYL-4-(DIMETHYLAMINO) AZOBENZENE IN RAT BILE

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概要

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• Metabolism of 3'-methyl-4-(dimethylamino) azobenzene (3'-Me-DAB) in the rat was examined by the ion cluster technique, using a mixture of non-labeled 3'-Me-DAB and its deuterated compound. Labeled 3'-Me-DAB in cotton seed oil was administered orally by a stomach tube. The bile collected during 24 hr was enzymically hydrolyzed. This sample was applied to an Amberlite XAD-2 column and the column was washed with water. The metabolites were eluted with methanol. The doublets of molecular ion in the mass spectra originating in the mixture of non-labeled and labeled dye were respectively recognized in the fractions separated by thin-layer chromatography. Twenty-four metabolites were identified for 3'-Me-DAB by this technique and the new metabolic pathway of the aminoazo dye at the site of ring methyl group was established. Effect of the ring methyl group on the carcinogenic action of aminoazo dyes is discussed.

• 公益社団法人日本薬学会の論文

著者

• MORI Yukio

  Gifu Pharmaceutical University

• Morishita Y

  First Department Of Pathology Gifu University School Of Medicine

• Toyoshi Kazumi

  Department Of Pathology Gifu University School Of Medicine

• Horie Masanobu

  Tokyo College Of Pharmacy

• Mori Yukio

  Laboratory Of Radiochemistry Gifu Pharmaceutical University

• TOYOSHI KAZUMI

  Gifu Pharmaceutical University

• Kumo Toshiya

  First Department Of Pathology Gifu University School Of Medicine

• Tamura Kazutoshi

  Department Of Oncological Pathology Cancer Center Nara Medical University

• HORI TOSHIRO

  Gifu College of Pharmacy

• Kinjo Tatsuya

  Tumor Pathology University Of Ryukyus Faculty Of Medicine

• Kinjo Tatsuya

  Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima

• Yoshimoto Masatoshi

  Surgical Center Nara Medical University Hospital

• Mizumoto Yasushi

  Department Of Oncological Pathology Cancer Center Nara Medical University

• Kawamori Toshihiko

  Department Of Pathology Gifu University School Of Medicine

• Toyoshi Kazumi

  Gifu Collgege Of Pharmacy

• Yoshimoto Masatoshi

  Gifu Pharmaceutical University

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