Effect of Diesel Exhaust Particles on House Dust Mite–Induced Airway Eosinophilic Inflammation and Remodeling in Mice

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概要

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• Recent research has focused on the effects of ambient particulate pollution and much evidence has indicated that particulate pollution is associated with the onset of asthma and allergy; however, the effect of diesel exhaust particles (DEP) on the development of allergen-induced airway remodeling has not been fully investigated in vivo. In the present study, we examined the effects of DEP on Dermatophagoides farinae allergens (Der f)–induced asthma-like phenotypes in mice. Mice were administered i.t. 8 times with Der f. DEP were injected i.t. with Der f 4 times throughout the experiment or twice at the sensitization period. In both cases, DEP aggravated Der f–induced increases in airway responsiveness to acetylcholine, the number of eosinophils and neutrophils in the bronchoalveolar lavage fluid (BALF), serum Der f–specific IgG1 levels, Th2 cytokines and transforming growth factor-β1 levels in BALF, and amount of hydroxyproline in the right lungs. Furthermore, goblet cell hyperplasia and subepithelial fibrosis were also markedly aggravated. These findings indicate that DEP can potentiate airway remodeling induced by repeated allergen challenge as well as Th2-drived airway hyperresponsiveness, eosinophilic inflammation, and IgG1 production and that DEP can exhibit adjuvant activity for airway remodeling, probably due to the enhancement of allergen sensitization and/or of Th2 polarizing pathways.

• 社団法人 日本薬理学会の論文

著者

• TANAKA Hiroyuki

  Laboratory of Marine Biotechnology and Microbiology, Graduate School of Fisheries Sciences, Hokkaido

• WAKAHARA Keiko

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University

• INAGAKI Naoki

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University

• NAGAI Hiroichi

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University

• Takeda H

  Department Of Pharmacology Gifu Pharmaceutical University

• Takahashi Go

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Nasu Reishi

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Hashimoto Mikiko

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Miyoshi Kosuke

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Takano Hirohisa

  National Institute for Environmental Studies, Japan

• Yamashita Hirotaka

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Inagaki Naoki

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Nagai Hiroichi

  Laboratory Of Clinical Pharmacology Gifu Pharmaceutical University

• Takano Hirohisa

  National Institute For Environmental Studies

• Yamashita Hirotaka

  Laboratory Of Biochemistry And Nutritional Chemistry Faculty Of Agriculture Kagoshima University

• Inagaki Naoki

  Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor

• Tsuchiya Hiroshi

  Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor

• Nasu Reishi

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Wakahara Keiko

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Miyoshi Kosuke

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Hashimoto Mikiko

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Takahashi Go

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Tanaka Hiroyuki

  Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Infor

• Inagaki Naoki

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Wakahara Keiko

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

• Tanaka Hiroyuki

  Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan

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