Correlation Between Serum Concentrations of B-Type Natriuretic Peptide and Albumin in Patients With Chronic Congestive Heart Failure
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概要
- 論文の詳細を見る
While B-type natriuretic peptide (BNP) and hypoalbuminemia are both predictors of major adverse cardiac events (MACE) in patients with congestive heart failure (CHF), whether these markers are correlated is not known. We retrospectively analyzed data collected in 85 patients presenting with CHF, a left ventricular (LV) ejection fraction (EF) < 50%, and non-ischemic heart disease, followed for a mean of 38 months. Statistical analysis was performed to 1) examine the relationship between a) baseline BNP or albumin concentrations and b) baseline clinical characteristics, 2) identify the correlates of changes in (Δ) BNP concentrations, and Δ albumin concentrations, and 3) ascertain the prognostic value of each variable. Log transformed BNP was correlated with New York Heart Association functional class, total protein and LVEF, while albumin was correlated with a history of diabetes mellitus and total protein. Δ BNP and Δ albumin concentrations between baseline and follow-up were correlated (P < 0.0001). The follow-up BNP and albumin concentrations were independent predictors of MACE.BNP and albumin were correlated with different baseline clinical characteristics. The long-term changes in the two markers were inversely correlated and both were independent predictors of CHF.
著者
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Fujiwara Hisayoshi
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Fujiwara Takako
Department Of Food Science Kyoto Women's University
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Sato Yukihito
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Takatsu Yoshiki
Department Of Cardiology And Nephrology Shizuoka Central Prefectural Hospital
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Yamamoto Erika
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Takatsu Yoshiki
Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki Hospital
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Sawa Takuma
Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki Hospital
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Sato Yukihito
Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki Hospital
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Yamamoto Erika
Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki Hospital
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