Tobacco Tar Components That Stimulate Nerve Growth Factor (NGF) Synthesis/Secretion of Mouse Astroglial Cells in Culture
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概要
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It is reported that nicotine, one of the major tobacco tar components, increases the acetylcholine level in the brain. As nerve growth factor (NGF) is thought to promote the differentiation and maintenance of cholinergic neurons in the brain that are damaged in Alzheimer's disease (AD) by the increment of acetylcholine synthesis, we studied the relationship between nicotine and various tobacco tar components and the NGF synthesis/secretion in cultured astroglial cells. We found that multi-phenol compounds and nicotine increased the NGF content in the conditioned medium. NGF induced by nicotine had the same biological activity, molecular weight, and antigenicity as mouse βNGF. Especially, nicotine potentiated the NGF-mediated survival of sympathetic nerve cells. Thus, in addition to its known excitatory effect on the central nervous system, nicotine also has the additional effects of stimulating NGF synthesis/secretion of astroglial cells and potentiating NGF action. This increased NGF in the brain may serve to promote neuronal survival.
- 社団法人日本農芸化学会の論文
- 1994-05-23
著者
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HAYASHI KYOZO
Department of Biology, Gifu Pharmaceutical University
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SHIMIZU Yoshiharu
Department of Community Health, School of Medicine, Tokai University
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Shimizu Yoshiharu
Department Of Public Health School Of Medicine Tokai University
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Shimizu Yoshiharu
Department Of Community Health School Of Medicine Tokai University
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Hayashi Kyozo
Department Of Biochemistry Osaka University Of Pharmaceutical Sciences
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Shimizu Y
Shinshu Univ. Nagano Jpn
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Murase Katsuhito
Department of Molecular Biology, Gifu Pharmaceutical University
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Murase Katsuhito
Department Of Molecular Biology Gifu Pharmaceutical University
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Hayashi Kyozo
Department Of Molecular Biology Gifu Pharmaceutical University
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Shimizu Yoshiharu
Department of Applied Chemistry, School of Advanced Science and Engineering, Waseda University
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