p-Hydroxybenzoate Esters Enhance Mouse Contact Hypersensitivity
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概要
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p-Hydroxybenzoate esters (parabens), which are often used in cosmetics as preservatives, have been reported to have estrogenic and anti-androgenic effects and to cause contact dermatitis. In this paper, we evaluate the effects of parabens on contact hypersensitivity, an allergic response to low molecular weight chemicals that causes contact dermatitis. Female BALB/c mice were administered 1200 mg/kg of butylparaben and sensitized by painting 3% 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (OXA) on their backs. Seven days later, the mice were challenged by painting 1% OXA on the ear and the ear thickness was measured. Ear auricles were excised and the RNA expressions of interleukin (IL)-18 and interferon (IFN)-γ were evaluated by reverse transcription-polymerase chain reaction (RT-PCR). Butylparaben enhanced ear swelling at 6 hr after the elicitation of allergy. Butylparaben at a dosage of 600 mg/kg was sufficient to aggravate contact hypersensitivity. Among the six parabens examined, butylparaben exerted the strongest allergy-enhancing activity. Butylparaben also enhanced the RNA expression of IL-18 before the challenge with OXA and the RNA expression of IFN-γ at 6 hr after the challenge. These results suggest that parabens could enhance IL-18 and IFN-γ expression and exacerbate mouse contact hypersensitivity to OXA.
- 社団法人 日本薬学会の論文
著者
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Nagase Hisamitsu
摂南大学 薬学部公衆衛生学
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NAGASE Hisamitsu
Department of Hygienics., Gifu Pharmaceutical University
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Sakazaki Fumitoshi
Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan
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Ueno Hitoshi
Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan
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Nakamuro Katsuhiko
Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan
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Nagase Hisamitsu
Department Of Hygienics Gifu Pharmaceutical University
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Ueno Hitoshi
Dep. Of Public Health & Preventive Pharmacology Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Ueno Hitoshi
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Nakamuro Katsuhiko
Department Of Hygienic Chemistry National Institute Of Hygienic Sciences
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Sakazaki Fumitoshi
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Nagase Hisamitsu
Department of Hygienics, Gifu Pharmaceutical University
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Ueno Hitoshi
Department of Chemistry, Faculty of Science, Kanazawa University
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