17β-Estradiol Primes Elicitation of Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide and Interferon-γ in Mouse Macrophage Cell Line J774.1
スポンサーリンク
概要
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The effects of estrogenic compounds on nitric oxide (NO) production by macrophages were examined. 17β-Estradiol promoted NO production triggered by lipopolysaccharide (LPS) and/or interferon (IFN)-γ in the mouse macrophage cell line J774.1. Other estrogen-like substances such as estrone, 17α-ethynylestradiol and bisphenol A also enhanced NO synthesis, but this NO synthesis was not activated by Ca^<2+> ionophore A23187. RT-PCR analysis demonstrated induction of inducible nitric oxide synthase (iNOS) mRNA in J774.1 cells exposed to 17β-estradiol. Although the estrogen receptor (ER) -antagonist ICI-182780 partially suppressed the promoting effect of 17β-estradiol on NOS activity, there was little ERα detectable by RT-PCR from J774.1 cells. These results suggest that ERs may participate only partially in iNOS mRNA transcription in J774.1 cells and that 17β-estradiol may act directly through other unknown intracellular signal transduction (s) that are activated by LPS and IFN-γ.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Ueno Hitoshi
Dep. Of Public Health & Preventive Pharmacology Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Ueno Hitoshi
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Ueno Hitoshi
Division Of Environmental Health Faculty Of Pharmaceutical Science Setsunan University
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Nakamuro K
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Sakazaki Humitoshi
Division of Environmental Health, Faculty of Pharmaceutical Sciences, Setsunan University
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Ido Ryoko
Division of Environmental Health, Faculty of Pharmaceutical Sciences, Setsunan University
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Nakamuro Katsuhiko
Division of Environmental Health, Faculty of Pharmaceutical Sciences, Setsunan University
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Ido Ryoko
Division Of Environmental Health Faculty Of Pharmaceutical Sciences Setsunan University
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Sakazaki Humitoshi
Division Of Environmental Health Faculty Of Pharmaceutical Science Setsunan University
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