Metabolism of Selenoamino Acids and Contribution of Selenium Methylation to Their Toxicity
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概要
- 論文の詳細を見る
Selenium (Se) is an essential trace element and a toxicant for animals. Selenocystine (CySeSeCy) and selenomethionine (SeMet), selenoamino acids, are one of the chemical forms in which selenium exists in foods. This review summarized recent studies on the relation of toxicity and metabolism of selenite, CySeSeCy and SeMet in experimental animals. Hepatotoxicity is caused by repeated oral administration of CySeSeCy. CySeSeCy is metabolized by reduced glutathione (GSH) and/or glutathione reductase to hydrogen selenide (H_2Se) via selenocysteine-glutathione selenenyl sulfide (CySeSG). The H_2Se is a key intermediate in the methylation process of inorganic and organic selenium compounds. Accumulation of H_2Se resulting from inhibition of the Se-methylation metabolism, the detoxification pathway of selenium, is found in animals following repeated oral administration of a toxic dose of CySeSeCy. The Se-methylation inhibition is caused by a reduction in the Sadenosylmethionine (SAM) level due to the repression of methionine adenosyltransferase activity. The excess of H_2Se produced by inhibition of methionine adenosyltransferase contributes to the hepatotoxicity caused by CySeSeCy. Moreover, SeMet is now known to be directly metabolized to monomethylselenol (MMSe) as selenide by γ-elimination enzyme in mouse liver. The disturbances in detoxification pathway of Se compounds such as methylation process may be involved in the development of selenosis.
- 公益社団法人日本薬学会の論文
- 2000-12-01
著者
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HASEGAWA Tatsuya
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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Hasegawa Tatsuya
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Nakamuro Katsuhiko
Faculty of Pharmaceutical Sciences, Setsunan University
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Nakamuro K
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Okuno Tomofumi
Faculty of Pharmaceutical Sciences, Setsunan University
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Nakamuro Katsuhiko
Faculty Of Pharmaceutical Sciences Setsunan University
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Okuno Tomofumi
Department Of Public Health & Preventive Pharmacology Faculty Of Pharmaceutical Sciences Setsuna
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Hasegawa Tatsuya
Faculty Of Pharmaceutical Sciences Setsunan University
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Hasegawa Tatsuya
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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