Cytotoxic Fatty Acid from Pleurocybella porrigens
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概要
- 論文の詳細を見る
The new conjugated ketonic fatty acid, porrigenic acid (1), was isolated as a cytotoxic constituent of Pleurocybella porrigens. The structure of 1 was elucidated using spectroscopic methods including 1D and 2D NMR and MS. The absolute stereochemistry of 1 was determined by application of the exciton chirality method. Compound 1 exhibited cytotoxic activity against myeloma THP-1 cells, but did not show any significant toxicity against B16F1 melanoma. This is the first report of the isolation and structural elucidation of the new cytotoxic constituent porrigenic acid (1) from the edible mushroom P. porrigens.
- 公益社団法人日本薬学会の論文
- 2007-12-01
著者
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TAKANO Fumihide
Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science an
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TAKATA Takanobu
Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science an
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HASEGAWA Tatsuya
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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Tatsuno Takanori
Dep. Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Sci. And Technol.
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Takano Fumihide
Dep. Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Sci. And Technol.
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Takano Fumihide
Kanazawa Univ. Kanazawa Jpn
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OHTA Tomihisa
Kanazawa University
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OHTA Tomihisa
Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science an
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Ohta Tomihisa
Kanazawa Univ. Kanazawa Jpn
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Ohta Tomihisa
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Fukui University
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ISHIBASHI Mayumi
Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science an
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Ishibashi Mayumi
Department Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Science And
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Hasegawa Tatsuya
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Ohta Tomihisa
Dep. Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Sci. And Technol.
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Takano Fumihide
Department Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Science And
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Tanaka Tomoaki
Department Of Pharmacognosy And Chemistry Of Natural Products Graduate School Of Natural Science And
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Takata Takanobu
Division Of Molecular Oncology And Virology Medical Research Institute Kanazawa Medical University
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Nakaya Naoki
Department Of Medical Oncology Kanazawa Medical University
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Hasegawa Tatsuya
Dep. Of Pharmacognosy And Chemistry Of Natural Products School Of Pharmacy And Pharmaceutical Sciences Kanazawa Univ.
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