SELECTIVE EFFECT OF CHRONIC LEAD INGESTION III : EFFECT ON DOPAMINE β-HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
スポンサーリンク
概要
- 論文の詳細を見る
Selectivity of lead effect on dopamine β-hydroxylase activity in regions of brain from rats postnatally exposed to lead was tested. Three groups of animals were prepared; (1) Rats exposed to lead at a low dose (0.05% PbAcetate: PbAc); (2) Rats exposed to lead at a high dose (0.2% PbAc); (3) Age-matched normal control rats. At 2, 4, 6 and 8 weeks of age weight of whole brain and body in each group were measured. At the same ages activities of dopamine β-hydoroxylase and Na^+/K^+-ATPase were measured in 5 brain regions of each animal. Exposure of rats to lead generally decreased Na^+/K^+-ATPase activity and showed alternative changes of dopamine β-hydroxylase activity were detected without concomitant changes of Na^+/K^+-ATPase activity were telencephalon and pons/medulla at 2 weeks of age and telencephalon, diencephalon and pons/medulla at 4 weeks of age and midbrain and pons/medulla at 6 weeks of age and cerebellum at 8 weeks of age in rats exposed to lead at a low dose, and those in rats exposed to lead at a high dose were midbrain at 6 weeks of age and cerebellum at 8 weeks of age. These data imply that noradrenergic nervous system in the brain regions described above could selectively be affected by lead.
- 日本トキシコロジー学会の論文
- 1993-02-25
著者
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KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
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Kuroiwa Y
Experimental Toxicology Group Sandoz Research Laboratory
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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KO Kwang
Department of Electrical and Electronic Engineering, Faculty of Engineering, Tokyo Institute of Tech
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Song Sun
Department Of Pharmacology College Of Pharmacy Seoul National University
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CHIN Kang
National Institute of Safety Research
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CHEONG Jae
Department of Pharmacology, College of Pharmacy, Seoul National University
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Ko Kwang
Department Of Pharmacology College Of Pharmacy Seoul National University
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Ko Kwang
Department Of Electrical And Electronic Engineering Faculty Of Engineering Tokyo Institute Of Techno
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Cheong Jae
Department Of Pharmacology College Of Pharmacy Seoul National University
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Song Sun
Department Of Chemical Engineering Dong-a University
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Kuroiwa Y
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Ko Kwang
韓国
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KO Kwang
Departmemt of Mechatronics, Gwangju Institute of Science and Technology
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CHEONG Jae
Department of Gastroenterology, Ajou University School of Medicine
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