Production of Poly(3-Hydroxybutyric-co-3-Hydroxyvaleric)acid Using Propionic Acid by pH Regulation

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概要

• 論文の詳細を見る

• Propionic acid has been used as a cosubstrate for the production of the biodegradable polymer, poly(3-hydroxybutyric-co-3-hydroxyvaleric)acid, by Alcaligenes eutrophus. Propionic acid is, however, known to inhibit growth of A. eutrophus at concentrations above 0.5g/l in the fermentation broth. In this study, the inhibition of the cell growth due to the presence of propionic acid was overcome by regulation of the pH. In the case of an initial pH of 7.5,A. eutrophus NCIMB 11599 continued to grow up to a propionic acid concentration of 5g/l, whereas no growth occurred in case of an initial pH of 6.5 in a wide concentration range of propionic acid. This enhanced uptake of propionic acid with pH changes seems to be due to a decrease in the concentration of undissociated propionic acid as an uncoupler. Continuous cultures were performed in a static pH mode. When the pH was maintained at 7.5 during the fermentation, the dry cell weigth was 50% higher than that when the pH was maintained at 6.8.

• 社団法人日本生物工学会の論文
• 1997-05-25

著者

• CHUNG Yoon

  Department of Anatomy, College of Medicine, Chung-Ang University

• Yeo Joo

  Department Of Sericulture And Entomology National Institute Of Agriculture And Technology

• Chung Yoon

  Department Of Anatomy College Of Medicine Chung-ang University

• Chung Yoon

  Department Of Chemical Engineering Seoul National University

• CHA HYUNG

  Department of Chemical Engineering, Seoul National University

• Cha Hyung

  Department Of Chemical Engineering Seoul National University

• Yeo Joo

  Department Of Chemical Engineering Seoul National University

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