Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice
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概要
- 論文の詳細を見る
A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators.
- 社団法人 日本薬理学会の論文
- 2007-06-20
著者
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YAMATODANI Atsushi
Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka Universi
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YAMAMOTO Kouichi
Department of Pathology, Yamanashi Medical College
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Yamamoto Kouichi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Yamatodani Atsushi
Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni
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Yamatodani Atsushi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamatodani A
Department Of Medical Physics School Of Allied Health Sciences Faculty Of Medicine Osaka University
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MORIYASU Saiko
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medic
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KUREYAMA Naoko
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medic
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OKAMURA Keita
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medic
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IKEDA Toshiji
Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka Univer
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Okamura Keita
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Ikeda Toshiji
Department Of Accelerator Science The Institute Of Scientific And Industrial Research Osaka Universi
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Kureyama Naoko
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Moriyasu Saiko
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamamoto Kouichi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamamoto Kouichi
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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