Establishment of an Animal Model for Radiation-induced Vomiting in Rats Using Pica

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated whether radiation-induced pica, a behavior characterized by the eating of a non-food substance, such as kaolin, can be used as an index of radiation-induced vomiting in rats. Since there was an individual difference in the susceptibility to pica, we selected rats that actually ate kaolin following X-ray irradiation, and used them for the experiment. The totalbody irradiation (TBI) increased kaolin consumption in a dose-dependent manner (sham, 0.05±0.03 (SEM) g; 2 Gy, 0.38±0.11 g; 4 Gy, 1.54±0.28 g; 8 Gy, 3.55±0.67 g), and the increased kaolin consumption after 4 Gy of TBI was inhibited by a pretreatment with the serotonin 5-HT_3 receptor antagonist ondansetron (2 mg/kg, i.p.) (saline, 1.49±0.33 g; ondansetron, 0.75±0.11g). Furthermore, 4 Gy of abdominal irradiation was more effective to induce pica than that of head irradiation (abdomen: 0.37±0.05 g, head: 0.06±0.01 g). These findings suggested that peripheral serotonergic pathway is predominantly involved in the development of radiationinduced pica in rats and that the radiation-induced pica could be useful as a behavioral index for the severity of radiation-induced vomiting in rats.

• 日本放射線影響学会の論文

著者

• TAKEDA Noriaki

  Department of Medical Systems Management, Faculty of Medicine, Kagawa Medical University

• YAMATODANI Atsushi

  Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka Universi

• YAMAMOTO Kouichi

  Department of Pathology, Yamanashi Medical College

• Yamamoto Kouichi

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicine

• Yamatodani Atsushi

  Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni

• Yamatodani Atsushi

  Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin

• Takeda Noriaki

  Department Of Otorhinolaryngology School Of Medicine University Of Tokushima

• Takeda Noriaki

  Department Of Medical Social Work Faculty Of Medical Welfare Kawasaki University Of Medical Welfare

• Yamatodani A

  Department Of Medical Physics School Of Allied Health Sciences Faculty Of Medicine Osaka University

• Yamamoto Kouichi

  Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin

• Yamamoto Kouichi

  Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine

関連論文

• Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice
• Impact of Health Professionals on Health Promotion Activities in Japanese Worksites
• ACE2 Mutant Mice Increase Cardiac Angiotensin II and Increase Incidence of Heart Failure in Response to Pressure Overload (Heart Failure, Basic 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Relationship of Bradykinin B2 Receptor Gene Polymorphism with Essential Hypertension and Left Ventricular Hypertrophy
• Association between Hepatocyte Growth Factor Gene Polymorphism and Essential Hypertension
• Free and Total Dopamine in Human Plasma: Effects of Posture, Age and Some Pathophysiological Conditions
• Association between Angiotensin II Type 1 Receptor Gene Polymorphism and Essential Hypertension : the Ohasama Study
• Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)
• Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their in Vivo Release of Neuronal Histamine Measured by Brain Microdialysis
• Thyroid peroxidase and gamma-GTP activities expressed in DIPN induced rat thyroid lesions : An enzyme histochemical study
• Analysis of functional differentiation and growth activity of DIPN induced rat thyroid tumors by immuno-double staining of Tg and BrdU
• Effects of HSP-117, a Novel Tachykinin NK_1-Receptor Antagonist, on Cisplatin-Induced Pica as a New Evaluation of Delayed Emesis in Rats
• Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H_1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate-Sensitized Rats
• Lower Plasma Adiponectin Concentration Increases Risk for Hypertension
• Abnormal expression of tyrosine hydroxylase not accompanied by phosphorylation at serine 40 in cerebellar Purkinje cells of ataxic mutant mice, rolling mouse Nagoya and dilute-lethal
• Sho-seiryu-to Suppresses Histamine Signaling at the Transcriptional Level in TDI-Sensitized Nasal Allergy Model Rats
• Study on the Longevity of Dental Restorations in Patients with Disabilities
• Stimulation of Histamine H_1 Receptor Up-Regulates Histamine H_1 Receptor Itself Through Activation of Receptor Gene Transcription
• Tissue Concentrations of Chlordanes in Mice after Long-term Exposures to Technical Grade Chlordane at Indoor Air Levels
• Dexamethasone Suppresses Histamine Synthesis by Repressing both Transcription and Activity of HDC in Allergic Rats
• DISTRIBUTION OF THE HISTAMINERGIC NEURON SYSTEM AND ITS PHYSIOLOGICAL FUNCTION IN RAT BRAIN
• Analysis of Beta3 Adrenergic Receptor Gene Polymorphism Using Noninvasive Samples Obtained at Scheduled Infant Health Checkups
• Study on Biological Monitoring of Fenpropathrin Exposure in Application by Utilizing Urinary 3-Phenoxybenzoic Acid Level
• A Study on Urine Cotinine for the Evaluation of Smoking Cessation
• The Effect of Haloperidol on the Histaminergic Neuron System in the Rat Brain
• The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells
• Strong suppression of the renin-angiotensin system has a renal-protective effect in hypertensive patients : High-dose ARB with ACE inhibitor (Hawaii) study
• Three-Dimensional Eye Movement Simulator Extracting Instantaneous Eye Movement Rotation Axes, the Plane Formed by Rotation Axes, and Innervations for Eye Muscles(Medical Engineering)
• Establishment of an Animal Model for Radiation-induced Vomiting in Rats Using Pica
• Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice
• Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice
• Decreased Response of Plasma Catecholamine to Stress in Diabetic Rats
• Mouse semaphorin H inhibits neurite outgrowth from sensory neurons
• Effective Health Checkup Methods for Adults with Intellectual Disabilities Part I: Intervention to Workplace Users with Autistic Tendencies
• Up-regulation of ferritin heavy chain mRNA expression in the rat skeletal muscle after denervation: detected by means of differential display
• Efficient Synthesis of trans- or cis-4(5)-(5-Aminomethyltetrahydrofuran-2-yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach toward Human Histamine H_4-Ligands
• Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice
• Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway
• The impact of visit-to-visit variability in blood pressure on renal function
• Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat
• The Role of the Autonomic Nervous System in the Thermic Effects of Protein and Carbohydrates in Rats.
• Dependency of histamine induced phasic and tonic contractions on intracellular and extracellular calcium in guinea pig tracheal smooth muscle.
• Effects of Inhibitors of Protein Kinase C on the Release and Synthesis of Histamine in Rat Basophilic Leukemia Cells (2H3).
• S1-3 Clinical significance of antihistamines(Antihistamine update (English Session))

もっと見る 閉じる

スポンサーリンク