Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)
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概要
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We investigated the effect of cisplatin on glutamate release in the hypothalamus of Suncus murinus measured by brain microdialysis. Dialysis samples were collected every 20 min for 1 h before and 3 h after the cisplatin (30 mg/kg, i.p.) administration with the animals also being observed for the development of emesis. Cisplatin increased glutamate levels within 1 h and this was closely associated with the occurrence of emesis. Pretreatment with the 5-HT3–receptor antagonist ondansetron (2 mg/kg, i.p.) inhibited both the emesis and the increased glutamate levels. These results suggest that hypothalamic glutamate is involved in cisplatin-induced emesis in Suncus murinus.
- 2009-04-20
著者
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Lin Ge
Department Of Pharmacology Faculty Of Medicine The Chinese University Of Hong Kong
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Chan Sze
Department Of Mechanical Engineering Kagoshima University
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Yamamoto Kouichi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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Yamatodani Atsushi
Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni
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Yamatodani Atsushi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamatodani A
Department Of Medical Physics School Of Allied Health Sciences Faculty Of Medicine Osaka University
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RUDD John
Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), Shatin
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ASANO Keiko
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medic
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Asano Keiko
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Chan Sze
Department Of Pharmacology Faculty Of Medicine The Chinese University Of Hong Kong
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Rudd John
Department Of Pharmacology Faculty Of Medicine The Chinese University Of Hong Kong
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Yamamoto Kouichi
Department Of Medical Physics And Engineering Division Of Health Sciences Graduate School Of Medicin
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Yamamoto Kouichi
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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