Serotonin : Independent Model of Cisplatin : Induced Emesis in the Ferret

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概要

• 論文の詳細を見る

• para-Chlorophenylalanine (PCPA, 100 - 200 mg/kg) was used as a pharmacological tool to characterize the 5-hydroxytryptamine (5-HT) involvement in the emesis occurring 24 hr after the administration of cisplatin (10 mg/kg) in the ferret. PCPA was effective to antagonize the initial 8 hr period of retching and vomiting, but potentiated the emesis that occurred during the remaining 8- to 24-hr observation period. Tissue samples removed from the brainstem at 24 hr post injection of cisplatin alone revealed an elevation of 5-HT, dopamine and homovanillic acid that was antagonized by the injection of PCPA. Cisplatin also induced increases in the urinary levels of 5-hydroxyindoleacetic acid that was similarly antagonized by PCPA. Results are discussed in terms of the relevance of 5-HT to the model of cisplatin (10 mg/kg)-induced emesis in the ferret compared to the problem of acute and delayed emesis in man. The residual or delayed phase of cisplatin-induced emesis may involve a 5-HT-independent mechanism.

• 社団法人 日本薬理学会の論文
• 1998-11-01

著者

• Rudd John

  Department Of Pharmacology Faculty Of Medicine The Chinese University Of Hong Kong

• Rudd John

  Department Of Pharmacology Faculty Of Medicine The Chinese University Ofhong Kong

• Naylor Robert

  Postgraduate Studies In Pharmacology The School Of Pharmacy University Ofbradford

• CHENG Celine

  Postgraduate Studies in Pharmacology, The School of Pharmacy, University ofBradford

• Cheng Celine

  Postgraduate Studies In Pharmacology The School Of Pharmacy University Ofbradford

関連論文

• Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)
• The Use of Microelectrode Array (MEA) to Study Rat Peritoneal Mast Cell Activation
• Serotonin : Independent Model of Cisplatin : Induced Emesis in the Ferret

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