Decreased Response of Plasma Catecholamine to Stress in Diabetic Rats
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概要
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Previously we reported that the heart norepinephrine concentration was markedly increased in diabetic rats. To further study the relationship between a disturbance in the autonomic nervous system and catecholamine metabolism in diabetes mellitus, the plasma catecholamine response to stress and catecholamine concentration of heart and adrenals were measured. Wistar male rats were made diabetic by streptozotocin and kept for 13 weeks. A silicon catheter was placed in the superior V. cava 1 week prior to the experiment. Insulin was injected scbcutaneously for 3 days once daily. After an overnight fast and without anesthesia, 1 ml of blood, a control sample, was obtained and then the animals were exsanguinated. The blood was mixed with 1 mM EGTA at a final concentration and centrifuged. The tissue was homegenized with 0.4 N perchloric acid containing 1 mM EGTA and centrifuged at 10, 000×g for 20 minutes. Catecholamines were determined by high performance liquid chromatography. Normal rats responded to blood withdrawal stress, and plasma catecholamines were markedly increased, but almost no increase or an actual decrease was observed in diabetic rats. These abnormal responses were improved by insulin treatment.<BR>Heart norepinephrine was increased significantly in the diabetic rats compared with the control rats and was reduced significantly by insulin injections. Adrenal epinephrine was also significantly increased in the diabetic rats compared with the control rats, but was not significantly reduced by insulin. These result suggest a possible disturbance of catecholamine secretion in the diabetic rats.
- 社団法人 日本内分泌学会の論文
著者
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TOCHINO Yoshihiro
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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Wada Hiroshi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Inoue Toru
Departments of Brain Surgery, National Hospital Organization Kyushu Medical Center
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NISHIKAWA Mitsuo
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate Schoo
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Yamatodani Atsushi
Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni
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Funakawa Susumu
Department Of Pharmacology Osaka City University Medical School
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Kishino Bunichiro
Department Of Gastroenterology And Hepatology Izumisano Municipal Hospital Rinku General Medical Cen
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FUSHIMI HISAKO
Department of Medicine, Sumitomo Hospital
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NAMIKAWA HIRAKI
Department of Medicine, Sumitomo Hospital
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NUNOTANI HARUO
Department of Medicine, Sumitomo Hospital
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Inoue Toru
Department Of Nephrology Osaka Medical College
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Wada Hiroshi
Department Of Bioengineering And Robotics Tohoku University
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TOCHINO YOSHIHIRO
Department of Medicine, Shionogi Central Laboratory
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KISHINO BUNICHIRO
Department of Medicine, Sumitomo Hospital
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YAMATODANI ATSUSHI
Department of Second Pharmacology, Osaka University School of Medicine
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NISHIKAWA MITSUO
Department of Medicine, Sumitomo Hospital
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INOUE TORU
Department of Medicine, Sumitomo Hospital
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WADA HIROSHI
Department of Second Pharmacology, Osaka University School of Medicine
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