Relationship between Molecular Weight Conversion and Renin Activity in Dog Renal Renin : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
スポンサーリンク
概要
- 論文の詳細を見る
A normal size form of renin, which seems to be a storage form in renin granules, changed neither in molecular weight nor activity by acidification to pH 3.0. High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acidification, accompanied with an increase in renin activity by about 5%. The molecular weight conversion by acidification appeared due to destruction or loss of binding ability of the renin binding substance which was present in the cytosol of renal cortical tissue. Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.
- 社団法人日本循環器学会の論文
- 1979-10-20
著者
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YAMAMOTO KENJIRO
Department of Pharmacology, Osaka City University Medical School
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IKEMOTO FUMIHIKO
Department of Pharmacology, Osaka City University Medical School
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KAWAMURA Minoru
Department of Internal Medicine, Iwate Prefectural Central Hospital
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Yamamoto Kenjiro
Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
The Department Of Pharmacology Osaka City University Medical School
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Funakawa Susumu
Department Of Pharmacology Osaka City University Medical School
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Kawamura Minoru
The Department Of Pharmacology Osaka City University Medical School
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Kawamura Minoru
Department Of Development Research Institute Of Bio-active Science Nippon-zoki Pharmaceutical Compan
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Ikemoto Fumihiko
Department Of Pharmacology Osaka City University Medical School
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Ikemoto Fumihiko
The Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
Dept. Of Pharm. Osaka City Univ. Medical School
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FUNAKAWA SUSUMU
Department of Medicine, Shionogi Central Laboratory
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KAWAMURA Minoru
Department of Cardiovascular Dynamics, Research Institute
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