Distribution of .ALPHA.1- and .ALPHA.2-adrenoceptors in brush border and basolateral membranes from rat kidney cortical tubules.
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概要
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To examine the localization of α-adrenoceptors within the kidney tubule, binding experiments with <SUP>125</SUP>I-HEAT and <SUP>3</SUP>H-yohimbine were performed using cortical homogenates, basoalteral membranes (BLM) and brush border membranes (BBM). B<SUB>max</SUB> values for <SUP>125</SUP>I-HEAT or <SUP>3</SUP>H-yohimbine binding were 2.3 or 2.0-fold that of the homogenate in BBM and 8.2- or 10.7-fold in BLM, respectively. K<SUB>d</SUB> values for <SUP>125</SUP>I-HEAT or <SUP>3</SUP>H-yohimbine were not significantly different between BBM and BLM. These results indicate that both types of α-adrenoceptors seem to be localized largely in the BLM.
- 公益社団法人 日本薬理学会の論文
著者
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Ito Keiichi
Department Of Mathematics College Of Liberal Arts Kyoto University
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Kawamura Minoru
Department Of Development Research Institute Of Bio-active Science Nippon-zoki Pharmaceutical Compan
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Akabane Satoshi
Department Of Pharmacology Research Institute For Brain And Blood Vessels Akita
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Matsushima Yohkazu
Department Of Cardiovascular Dynamics Research Institute National Cardiovascular Center
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KAWAMURA Minoru
Departments of Internal Medicine, National Cardiovascular Center Research Institute
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AKABANE Satoshi
Departments of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
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AKABANE Satoshi
Department of Cardiovascular Dynamics, Research Institute
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ITO Keiichi
Departments of Internal Medicine, National Cardiovascular Center Research Institute
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Ito Keiichi
Department of Cardiology, The Jikei University School of Medicine
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