DIVALENT CATION TRANSPORT IN KIDNEY SLICES. I. PROPERTIES OF CALCIUM TRANSPORT IN SLICES OF RAT KIDNEY CORTEX AND THE EFFECTS OF DIURETICS
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概要
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Correlative studies on transports of Ca<SUP>2+</SUP> and Na<SUP>+</SUP> and the properties of Ca<SUP>2+</SUP> transport were carried out in rat kidney cortex slices. Ouabain had no effect on the Ca<SUP>2+</SUP> transport but did inhibit the Na<SUP>+</SUP> transport extensively. With addition of 2, 4-dinitrophenol to the incubation medium, or under the anaerobic conditions, the effluxes of Ca<SUP>2+</SUP> and Na<SUP>+</SUP> were inhibited while the Ca<SUP>2+</SUP> influx was enhanced significantly. Sulfhydryl inhibitors such as ethacrynic acid, mersalyl and p-chloromercuribenzoic acid suppressed Ca<SUP>2+</SUP> efflux and stimulated Ca<SUP>2+</SUP> influx. When the slices of kidney cortex were treated with these inhibitors, there was a reduction in the content of cellular ATP. The present results suggest that Ca<SUP>2+</SUP> transport may be partly independent of Na<SUP>+</SUP> transport, and that Ca<SUP>2+</SUP> efflux may require energy-yielding processes.
- 社団法人 日本薬理学会の論文
著者
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GEMBA MUNEKAZU
Department of Pharmacology, Osaka College of Pharmacy
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MATSUSHIMA Yohkazu
Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center
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Matsushima Yohkazu
Department Of Cardiovascular Dynamics Research Institute National Cardiovascular Center
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Gemba Munekazu
Department Of Pharmacology Osaka College Of Pharmacy
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