EFFECT OF DIURETICS ON ION TRANSPORT OF KIDNEY CORTEX MITOCHONDRIA:1. INHIBITION OF ION ACCUMULATION BY ETHACRYNIC ACID AND FUROSEMIDE
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Rat kidney cortex mitochondria accumulated calcium remarkably in the absence of phosphate in the medium. ATP-dependent calcium and magnesium accumulation in rat kidney cortex mitochondria were inhibited by ethacrynic acid and furosemide, and the potassium accumulation stimulated by valinomycin was also inhibited by both diuretics. Oxygen consumption of kidney cortex mitochondria, on the other hand, was depressed by ethacrynic acid, but not at all by furosemide. Studies of this report place major emphasis upon the relationship between the effects of both diuretics on ion accumulation and on electron transport system.
- 公益社団法人 日本薬理学会の論文
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