EFFECT OF VERAPAMIL ON THE CALCIUM AND MAGNESIUM TRANSPORTS OF RAT KIDNEY CORTEX MITOCHONDRIA
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概要
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The effect of verapamil on Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> accumulation was investigated in isolated rat kidney cortex mitochondria. For the 50% inhibition of Ca<SUP>2+</SUP> accumulation, 2×10<SUP>-4</SUP> M verapamil concentration was required in the presence of ATP (2 mM) and phosphate (5 mM). Omission of phosphate from the medium increased the inhibitory effect of verapamil on Ca<SUP>2+</SUP> accumulation. Verapamil had no effect on Ca<SUP>2+</SUP> accumulation in the presence of both ATP and succinate (7.8 mM), but further addition of phosphate resulted in a significant inhibition of Ca<SUP>2+</SUP> accumulation by verapamil. Mg<SUP>2+</SUP> accumulation of mitochondria was similarly depressed by verapamil. The same tendency was found as for the modification of verapamil effect by acetate in mitochondrial Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> accumulation. Succinate oxidation of mitochondria was not affected by verapamil in the absence of phosphate, but was inhibited by verapamil in the presence of phosphate. Therefore, it seemed reasonable to assume that the depression of Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> transport of mitochondria by verapamil is modulated by permeant anions.
- 社団法人 日本薬理学会の論文
著者
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GEMBA MUNEKAZU
Department of Pharmacology, Osaka College of Pharmacy
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KOHDA Chieko
Department of Pharmacology, Osaka College of Pharmacy
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Gemba Munekazu
Department Of Pharmacology Osaka College Of Pharmacy
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