EFFECTS OF PROSTAGLANDIN A_2 AND E_2 ON RENAL FUNCTION AND RENIN RELEASE
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概要
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Effects of prostaglandin A_2 (PGA_2) and E_2 (PGE_2) on renin release and intrarenal blood flow distribution were studied in dogs anesthetised with pentobarbital. Plasma renin activity (PRA) was measured by radioimmunoassay. Intrarenal distribution of blood flow was determined by means of a radioactive microsphere method. Intrarenal arterial administration (IRA) of PGA_2 at a rate of 0.1 μg/min caused an increase in renal blood flow (RBF) and a slight increase in urine flow (UF) without any change of renal arterial pressure (RAP). Renal venous PRA was slightly but significantly increased following PGA_2 infusion into the renal artery (0.1 μg/min). Doses of PGA_2 (0.5 μg/min, IRA) and PGE_2 (0.1 μg/min, IRA) had maximum effect on RBF without changing RAP. Both PGA_2 (0.5 μg/min, IRA) and PGE_2 (0.1 μg/min, IRA) increased RBF, UF and urinary sodium and potassium excretion, but did not influence on Glomerular filtration rate (GFR). PGA_2 (0.5 μg/min, IRA) increased significantly arterial and renal venous PRA while, PGE_2 (0.1 μg/min, IRA) had no effect on arterial or renal venous PRA. Concerning the intrarenal distribution of blood flow, both PGA_2 (0.5 μg/min, IRA) and PGE_2 (0.1 μg/min, IRA) resulted in an increased flow rate in each cortical zone, but the zonal response pattern was not uniform and was characterzed by a progressively proportional increase in flow from the superfical to the deep cortex. Thus, the percentage distribution was significantly changed, showing a redistribution of blood flow from the superficial cortex to the deep cortex. Intravenous administration (IV) of 0.5 μg/min PGA_2 reduced blood pressure by 15-20 mmHg but did not change RBF. UF showed a slight decrease following PGA_2 infusion intravenously (0.5 μg/min, IV) and increased significantly arterial and renal venous PRA. PGE_2 (0.5 μg/min, IV) caused a reduction in RAP by 10-15 mmHg. RBF and UF showed a small increase following PGE_2 infusion intravenously (0.5 μg/min). Both arterial and renal venous PRA were increased by intravenous administration of 0.5 μg/min PGE_2, but the difference was not significant. The data suggested that both PGA_2 and PGE_2 have similar effects on renal hemodynamics and urine formation. It is likely that PGA_2 stimulates renin release but PGE_2 does not.
- 社団法人日本循環器学会の論文
- 1978-09-20
著者
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YAMAMOTO KENJIRO
Department of Pharmacology, Osaka City University Medical School
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Kishimoto Taketoshi
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Yamamoto Kenjiro
Osaka City University Medical School
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Maekawa Masanobu
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Abe Youichi
Department Of Pharmacology Osaka City University Medical School
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Maeda Tsutomu
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Yamamoto Kenjiro
Department Of Pharmacolory Osaka City University Medical School
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MATSUMURA TOSHIHIRO
Dept. of Urology, Osaka City University Medical School, Osaka, Japan
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ABE YOUICHI
Dept, ofPharmacology, Osaka City University Medical School, Osaka, Japan
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YAMAMOTO KENJIRO
Dept, of Pharmacology, Osaka City University Medical School, Osaka, Japan
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Yamamoto Kenjiro
Departments Of Pharmacology And Urology Osaka City University Medical School
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Yamamoto Kenjiro
Dept. Of Pharm. Osaka City Univ. Medical School
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Matsumura Toshihiro
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Abe Youichi
Department of Pharmacology, Osaka City University Medical School
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