RELATIONSHIP BETWEEN INTRARENALDISTRIBUTION OF BLOOD FLOW AND RENIN SECRETION DURING URETERALOCCLUSION
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概要
- 論文の詳細を見る
The present study was undertaken to evaluate the relationship between renin secretion from the denervated kidney and intrarenal distribution of blood flow during reductions in renal perfusion pressure by partial constriction of the aorta with and without ureteral occlusion in the anesthetized dog. In addition, renin contents in different zones of the kidney were measured. A reduction in renal arterial pressure from normal pressure (125-135 mmHg) to 77 mmHg resulted in significant increase in renin secretion and redistribution of cortical blood flow. A further reduction of renal arterial pressure to 51 mmHg produced a marked increase in renin secretion rate (RSR) without further changers in the intrarenal distribution pattern of blood flow. The pressure reductions during ureteral occlusion increased RSR without any change in the distribution pattern of blood flow, and a decrease in the amounts of extractable renin was found in the outer cortex of the experimental kidney. These findings suggest that renin release occurs mainly in the outer cortex, and this process may be stimulated when the mechanism of autoregulation fails as the perfusion pressure approaches to the lower range autoregulation in the outer cortex.
- 社団法人日本循環器学会の論文
- 1976-08-20
著者
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OKAHARA TAKESHI
Department of Pharmacology, Osaka City University Medical School
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YAMAMOTO KENJIRO
Department of Pharmacology, Osaka City University Medical School
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Kishimoto Taketoshi
Dept. Of Urology Osaka City University Medical School Osaka Japan
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Yamamoto Kenjiro
Osaka City University Medical School
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Abe Youichi
Department Of Pharmacology Osaka City University Medical School
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Yamamoto Kenjiro
Department Of Pharmacolory Osaka City University Medical School
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Okahara Takeshi
Department Of Pharmacology Osaka City University Medical School
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ABE YOUICHI
Osako City University Medical School
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KISHIMOTO TAKETOSHI
Osako City University Medical School
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YAMAMOTO KENJIRO
Osako City University Medical School
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Yamamoto Kenjiro
Departments Of Pharmacology And Urology Osaka City University Medical School
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Yamamoto Kenjiro
Dept. Of Pharm. Osaka City Univ. Medical School
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Abe Youichi
Department of Pharmacology, Osaka City University Medical School
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