Sandwich Radioimmunoassay of Human Plasma Renin Using Two Monoclonal Antibodies : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

概要

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Plasma immunoreactive renin was measured by sandwich radioimmunoassay, under various physiological and pathological conditions. Enzymatic activities of active renin and trypsin-activatable inactive renin were also measured. There was a significant correlation between plasma immunoreactive renin concentration (IRRC) and total (active plus inactive) renin concentration, as estimated by enzymatic activity. In plasma from normotensive volunteers and hypertensive patients, the IRRC were 279 ± 37 pg/ml and 268 ± 29 pg/ml, respectively. After the intravenous injection of furosemide, the plasma IRRC in normotensive volunteers increased significantly. IRRC was significantly higher in plasma from juvenile diabetics than in plasma form age-matched disease-free children. Thus, renin secretion in children with diabetes mellitus is increased.
社団法人日本循環器学会の論文
1988-11-20