Vascular Responsiveness to Angiotensin II and Phenylephrine, the Tubular Function and the Prostaglandin, Renin-Angiotensin System in a Patient with Bartters Syndrome

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In a 39-yr-old female patient with Bartters syndrome, vascular responsiveness to angiotensin II and phenylephrine was studied. Pressor responses to angiotensin II and to phenylephrine were markedly decreased prior to treatment and were improved by administration of indomethacin, dextran, KCI, captopril, propranolol or pindolol. Moreover, the responses of total peripheral vascular resistence to angiotensin II and phenylephrine were markedly decreased before treatment and were improved by the treatment. A relatively low fractional distal chloride reabsorption was found, and that was not changed after the administration of KCI or indomethacin. The results of this patient were compatible with the primary cause of Bartters syndrome, defective chloride reabsorption at the loop of Henle, but the possibility of an abnormality in the vascular wall could not be denied.(Internal Medicine 31 : 134-139, 1992)