Vasopressin as a Possible Contributor to Hypertension : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES

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概要

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• The role of vasopressin as a pressor agent to the hypertensive process was examined. Vasopressin plays a major role in the pathogenesis of DOCA-salt hypertension, since the elevation of blood pressure was not substantial in the rats with lithium-treated diabetes insipidus after DOCA-salt treatment. Administration of DDAVP which has antidiuretic action but minimal vasopressor effect failed to increase blood pressure to the levels observed after administration of AVP. Furthermore, the pressor action of vasopressin appears to be important in the development of this model of hypertension, since the enhanced pressor responsiveness to the hormone was observed in the initial stage of hypertension. Increased secretion of vasopressin from neurohypophysis also promotes the function of the hormone as a pathogenetic factor in hypertension. An unproportional release of vasopressin compared to plasma osmolality may be induced by the absence of an adjusting control of angiotensin II forming and receptor binding capacity for sodium balance in the brain. However, the role of vasopressin remains to be determined in human essential hypertension.

• 社団法人日本循環器学会の論文
• 1984-02-20

著者

• Yazaki Y

  Department Of Gene Diagnostics And Therapeutics International Medical Center Of Japan

• Ashida Terunao

  The Division Of Cardiovascular Diseases The Institute For Adult Diseases Asahi Life Foundation

• Ashida Terunao

  朝日生命成人病研究所附属丸の内病院

• YAZAKI Yoshio

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Yazaki Yoshio

  The Third Department Of Medicine And The Department Of Radiology University Of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yoshizumi Masao

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• OHUCHI YASUYOSHI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ASHIDA TERUNAO

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TSAI RON-CHI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Tsai Ron-chi

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ashida Terunao

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ohuchi Yasuyoshi

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo.

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