Cellular and Molecular Bases for the Immunopathology of the Myocardial Cell Damage Involved in Acute Viral Myocarditis with Special Reference to Dilated Cardiomyopathy : MOLECULAR ANALYSIS OF THE PATHOPHYSIOLOGY OF CARDIOMYPATHY

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概要

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• Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of the myocardial cell damage involved in viral myocarditis. To investigate the cellular and molecular bases of both target cells and effector cells for cell-mediated cytotoxicity involved in viral myocarditis and dilated cardiomyopathy, we first examined the expression of major histocompatibility complex (MHC) antigens and a cell adhesion molecule, intercellular adhesion molecule-1 (ICAM-1) in myocardial cells of a murine model of viral myocarditis and in patients with acute myocarditis and dilated cardiomyopathy. Secondly, we analyzed the characteristics of the infiltrating cells in the heart, especially the expression of a cytolytic factor, perforin. We found that Coxsackievirus B3 (CVB3)-induced murine acute myocarditis resulted in enhanced expression of MHC (class I) antigens and ICAM-1 on myocardial cells, and that perforin was abundantly expressed in NK (natural killer)-like large granular lymphocytes (LGL), which represent the main infiltrating cell type in the early stage. Immunoelectron microscopic study showed killer cells directly damaging cardiac myocytes by the release of perforin. Perforin was also expressed in the infiltrating cells in the heart of a patient with acute myocarditis. Both MHC antigens and ICAM-1 were clearly expressed in the hearts of patients with acute myocarditis and dilated cardiomyopathy. These data provided direct evidence that cell-mediated cytotoxicity plays a critical role in the myocardial cell damage involved in viral myocarditis.

• 社団法人日本循環器学会の論文
• 1992-10-20

著者

• Yamazaki Tsutoinu

  Department Of Clinical Epidemiology And Systems University Of Tokyo

• Yazaki Yoshio

  東京大学 医学系研究科臨床疫学

• Seko Yoshinori

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Seko Yoshinori

  The Third Department Of Internal Medicine University Of Tokyo

• Naito Shigeto

  The Institute For Adult Diseases Asahi Life Foundation

• YAGITA Hideo

  Department of Immunology, Juntendo University School of Medicine

• Imataka Koji

  The Institute For Adult Diseases Asahi Life Foundation

• Imataka Kouji

  The Institute For Adult Diseases Asahi Life Foundation

• Shinkai Yoichi

  Department Of Immunology School Of Medicine Juntendo University

• YAZAKI Yoshio

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Fujii Jun

  the Institute for Adult Diseases Asahi Life Foundation

• OKUMURA KO

  Department of Urology, School of Medicine, Jutendo University

• Yoshino S

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Okumura K

  Juntendo Univ. School Of Medicine Tokyo Jpn

• Okumura K

  Department Of Immunology Juntendo University

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• SEKO YOSHINORI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• YAMAZAKI TSUTOMU

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Shinkai Yoichi

  Departmemt Of Internal Medicine Kure National Hospital

• Yoshino Shinichi

  Department Of Joint Disease And Rheumatism Nippon Medical School

• Imataka Kouji

  The Institute For Adult Disenses Asahi Life Foundation

• Yagita H

  Department Of Immunology Juntendo University

• Yagita Hideo

  Department Of Immumology Juntendo University School Of Medicine

• Seko Yoshinori

  The Institute For Adult Diseases Asahi Life Foundation

• Fujii Jun

  The Institute For Adult Disenses Asahi Life Foundation

• Okumura Ko

  Department Of Engineering Physics Chubu University

• Yoshino S

  Department Of Joint Disease And Rheumatism Nippon Medical School

• Imataka Koji

  Center For Cardiovascular Disease Mitsui Memorial Hospital.

• Yazaki Yoshiro

  Third Department Of Internal Medicine University Of Tokyo

• Seko Yoshinori

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Seko Yoshinori

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yamazaki Tsutomu

  Department Of Clinical Epidemiology & Systems Graduate School Of Medicine The University Of Toky

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo.

• Okumura Ko

  School Of Medicine Juntendo University

• Okumura Ko

  Department Of Dermatology Juntendo University School Of Medicine

• Fujii Jun

  The Institute for Adult Diseases, Asahi Life Foundation

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