Perforin-Secreting Killer Cell Infiltration in the Aortic Tissue of Patients With Atherosclerotic Aortic Aneurysm

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概要

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• Cell-mediated immunity has been implicated in the pathogenesis of vascular cell injury in patients with atherosclerotic aortic aneurysms. To clarify the immunologic mechanisms involved, we examined the expression of a cytolytic factor, perforin, in infiltrating cells from aortic tissue samples taken from 6 patients with atherosclerotic aortic aneurysms. Immunohistochemical studies showed that the infiltrating cells consisted mainly of macrophages, natural killer (NK) cells, cytotoxic T lymphocytes (CTLs), and T helper cells, and that perforin was expressed in NK cells and CTLs. Immunoelectron microscopic studies demonstrated that the infiltrating cells released massive amounts of perforin directly on to the surface of arterial vascular cells. These findings provide the first direct evidence that some of the infiltrating cells in the aortic tissue consist of killer cells, and strongly suggest that these killer cells, especially NK cells and CTLs, may play a critical role in the vascular cell injury caused by atherosclerotic aortic aneurysm by releasing perforin.

• 社団法人日本循環器学会の論文
• 1997-11-20

著者

• Yazaki Y

  Department Of Gene Diagnostics And Therapeutics International Medical Center Of Japan

• Yazaki Yoshio

  東京大学 医学系研究科臨床疫学

• Seko Yoshinori

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Seko Yoshinori

  The Third Department Of Internal Medicine University Of Tokyo

• YAGITA Hideo

  Department of Immunology, Juntendo University School of Medicine

• YAZAKI Yoshio

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OKUMURA KO

  Department of Urology, School of Medicine, Jutendo University

• Yoshino S

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Okumura K

  Juntendo Univ. School Of Medicine Tokyo Jpn

• Okumura K

  Department Of Immunology Juntendo University

• Yazaki Yoshio

  The Third Department Of Medicine And The Department Of Radiology University Of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Matsuo Hiroshi

  Division of Cardiology,Tokyo Metropolitan Geriatric Hospital,the Second Dept.Med. , and tlle Dept.of

• SEKO YOSHINORI

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TADA Yusuke

  Second Department of Surgery, Yamanashi Medical University

• Yoshino Shinichi

  Department Of Joint Disease And Rheumatism Nippon Medical School

• Yagita H

  Department Of Immunology Juntendo University

• Yagita Hideo

  Department Of Immumology Juntendo University School Of Medicine

• Seko Yoshinori

  The Institute For Adult Diseases Asahi Life Foundation

• Sato Osamu

  Second Department of Surgery, Faculty of Medicine, University of Tokyo

• Takagi Atsuhiko

  Second Department of Surgery, Faculty of Medicine, University of Tokyo

• Sato O

  Second Department Of Surgery Faculty Of Medicine The University Of Tokyo

• Yazaki Yoshio

  The Third Department Of Internal Medicine University Of Tokyo

• Okumura Ko

  Department Of Engineering Physics Chubu University

• Yoshino S

  Department Of Joint Disease And Rheumatism Nippon Medical School

• Tada Y

  Second Department Of Surgery Faculty Of Medicine

• Tada Yusuke

  山梨医科大学 2外

• Tada Yusuke

  Second Department Of Surgery

• Yazaki Yoshiro

  Third Department Of Internal Medicine University Of Tokyo

• Takayama Y

  Department Of Surgery Kanto Central Hospital

• Seko Yoshinori

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Seko Yoshinori

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yazaki Yoshio

  The Third Dept. Of Medicine University Of Tokyo

• Takagi Atsuhiko

  Second Department Of Surgery Faculty Of Medicine University Of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo.

• Okumura Ko

  School Of Medicine Juntendo University

• Matsuo Hiroshi

  Division Of Angiology Department Of Internal Medicine National Cardiovascular Center

• Okumura Ko

  Department Of Dermatology Juntendo University School Of Medicine

• TADA Yusuke

  Second Department of Surgery, Faculty of Medicine

• Takayama Yutaka

  Second Department of Surgery, Faculty of Medicine

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