Distribution of Cardiac Myosin Isozymes in Cardiomyopathy : Immunohistochemical and Gene Analysis : SYMPOSIUM ON CURRENT STATUS OF DILATED CARDIOMYOPATHY : 50th Annual Scientific Session of the Japanese Circulation Society

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概要

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• We characterized cardiac myosin isoforms by immunohistochemical approaches using monoclonal antibodies and demonstrated the existence of a distinctive type of cardiac myosin heavy chain which predominates in the fetal stage but is depressed during postnatal development. Furthermore, we showed that this type of cardiac myosin heavy chain was ;markedly expressed in patients with dilated cardiomyopathy. The results suggested that the pathologic process involved in dilated cardiomyopathy affects myocardial differentiation by the inhibition of the myosin gene switching that normally occurs during muscle maturation. However, we could not find any polymorphism in myosin gene in our population sample of dilated cardiomyopathy. The pathophysiological role of fetal type cardiac myosin expression in dilated cardiomyopathy will be clarified by the characterization of the myosin near future.

• 社団法人日本循環器学会の論文
• 1987-06-20

著者

• Yazaki Y

  Department Of Gene Diagnostics And Therapeutics International Medical Center Of Japan

• Kawana Masatoshi

  Department Of Cardiology The Heartinstitute Of Japan Tokyo Women's Medicalcollege

• Kimata Shin-ichi

  Tokyo Women's Medical College

• Kawana Masatoshi

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yazaki Yoshi

  International Medical Center Of Japan

• Tsuchimochi Hidetsugu

  The Third Department of Internal Medicine, University of Tokyo

• KURABAYASHI MASAHIKO

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Kurabayashi Masahiko

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• KIMATA Shin-ichi

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Kimata Shin-ichi

  Department Of Iternal Medicine The Heart Institute Of Japan Tokyo Women's Medical College

• Kimata Shin-ichi

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo And The Institute

• Kimata Shin-ichi

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Tsuchimochi Hidetsugu

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• YAZAKI YOSHI

  The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo and The Institut

• Kimata Shinichi

  Department Of Cardiology Tokyo Women's Medical College

• Kimata Shinichi

  Heart Institute Japan. Tokyo Women's Medical College

• Tsuchimochi Hidetsugu

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo And The Institute

• Tsuchimoch Hidetsugu

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Kurabayashi Masahiko

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo And The Institute

• Tsuchimochi Hidetsugu

  東京大学 第3内科

• Kurabayashi Masahiko

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo And The Institute Of Japan Tokyo Women's Medical College

• Tsuchimochi Hiditsugu

  Third Department Of Internal Medicine University Of Tokyo

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