Applications of Anticardiac Myosin Monoclonal Antibodies in the Diagnosis of Heart Disease : PANEL DISCUSSION ON PROGRESS IN NONINVASIVE CARDIAC DIAGNOSIS

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概要

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• We have developed anticardiac myosin antibodies, especially monoclonal antibodies, for helping in the diagnosis of heart disease. Our investigations were divided into three research projects. 1. We visualized the distribution of myosin isozymes in human atrial and ventricular myocardium by an immunofluorescence staining method using monoclonal antibodies specific for individual human cardiac myosin isozymes. We also revealed the redistribution of these cardiac myosin isozymes in an overloaded condition. The isozymic pattern of cardiac myosin was changed from the atrial type to the ventricular type in the overloaded atrium. This isozymic redistribution can be considered as physiological adaptive mechanism to meet increased cardiac work during overload. 2. We developed a new method of imaging for myocardial infarction by single photon emission tomography using labelled monoclonal antibody specific for cardiac myosin heavy chain. Specific localization of the labelled antibody was demonstrated in the infarcted area and no accumulation of radioactivity was shown in the bone matrix as observed in ^<99m>Tc pyrophosphate images. 3. We developed a sensitive radioimmunoassay of cardiac myosin light chain I (LCI) and demonstrated that peak serum levels of LCI in the patients with acute myocardial infarction correlated well with the left ventricular ejection fraction. Furthermore, LCI release from the infarcted myocardium was not affected by coronary reperfusion due to intracoronary thrombolysis. Thus, serial determinations of serum LCI better quantify the extent of myocardial damage even after coronary reperfusion in acute myocardial infarction.

• 社団法人日本循環器学会の論文
• 1985-07-20

著者

• Isobe Mitsuaki

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Nagai R

  Department Of Cardiology The University Of Tokyo

• Iemitsu Motoyuki

  筑波大学先端学際領域研究センター

• Iemitsu Motoyuki

  Cardiovascular Division Department Of Internal Medicine Institute Of Clinical Medicine

• Isobe Mitsuaki

  東京大学 先端臨床医学開発講座

• Ueda Seigo

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ueda Seigo

  東京大学

• YAZAKI Yoshio

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Nagai Ryozo

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Isobe Mitsuaki

  Graduate School Of Medicine Tokyo Medical And Dental University

• Takaku Fumimaro

  The Third Department of Internal Medicine, University of Tokyo

• Tsuchimochi Hidetsugu

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Isobe Mitsuaki

  Third Department of Medicine, University of Tokyo

• TAKAKU FUMIMORO

  Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Isobe Mituaki

  The Third Department Of Medicine And The Department Of Radiology University Of Tokyo

• Iemitsu Motoyuki

  Graduate School Of Medicine Tokyo Medical And Dental University

• Takaku Fumimaro

  The Third Department Of Internal Medicine University Of Tokyo

• Tsuchimochi Hidetsugu

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Isobe Mitsuaki

  The Cardiovascular Department Tokyo Medical And Dental University

• Isobe Mitsuaki

  The Third Department Of Medicine And The Department Of Radiology University Of Tokyo

• Tsuchimoch Hidetsugu

  The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ishibashi Miyuki

  The Third Department Of Internal Medicine Faculth Of Medicine University Of Tokyo

• Isobe Mitsuaki

  Third Department Of Medicine University Of Tokyo

• Takaku Fumirnaro

  The Third Dept. Of Medicine University Of Tokyo

• Nagai Ryozo

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Yazaki Yoshio

  Third Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo.

• Takaku Fumimaro

  The Third Dept. Of Medicine University Of Tokyo

• Tsuchimochi Hidetsugu

  東京大学 第3内科

• Tsuchimochi Hidetsugu

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Isobe Mitsuaki

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University Graduate School Of Medicine

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