RELATIONSHIP BETWEEN PLASMA LEVELS OF ATRIAL NATRIURETIC PEPTIDE AND CYCLIC GUANOSINE MONOPHOSPHATE IN PATIENTS WITH HEART DISEASES
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概要
- 論文の詳細を見る
The relation of plasma levels of atrial natriuretic peptide (ANP) to those of cyclic 3', 5'-guanosine monophosphate (cGMP) was studied in 43 patients with various heart diseases. Plasma levels of both ANP and cGMP were significantly (p < 0.001) elevated in 34 patients with chronic heart diseases, and a significant positive correlation was observed between the two variables (r = 0.706, 0 < 0.01). Clinical improvement of congestive heart failure resulted in a concomitant decrease in plasma ANP and cGMP levels in 6 patients. In 3 patients with paroxysmal atrial fibrillation, plasma levels of ANP and cGMP increased markedly during arrhythmia. These results indicate that increased circulating ANP may stimulate cGMP production in target cells, which in turn raises plasma levels of cGMP in humans.
- 社団法人日本循環器学会の論文
- 1988-01-20
著者
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Isobe Mitsuaki
The Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Imataka Koji
The Institute For Adult Diseases Asahi Life Foundation
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Imataka Kouji
The Institute For Adult Diseases Asahi Life Foundation
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Fujii Jun
the Institute for Adult Diseases Asahi Life Foundation
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NAKAOKA HIDEAKI
The Institute for Adult Diseases, Asahi Life Foundation
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KITAHARA YOUNOSUKE
The Institute for Adult Diseases, Asahi Life Foundation
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ISHIBASHI MIYUKI
The Third Department of Internal Medicine, Faculth of Medicine, University of Tokyo
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YAMAJI TOHRU
The Third Department of Internal Medicine, Faculth of Medicine, University of Tokyo
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Isobe Mitsuaki
CENTER FOR CARDIOVASCULAR DISEASE
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Yamaji Tohru
The Third Department Of Internal Medicine Faculth Of Medicine University Of Tokyo
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Imataka Kouji
The Institute For Adult Disenses Asahi Life Foundation
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Ishibashi Miyuki
The Third Department Of Medicine University Of Tokyo
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Fujii Jun
The Institute For Adult Disenses Asahi Life Foundation
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Imataka Koji
Center For Cardiovascular Disease Mitsui Memorial Hospital.
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Isobe Mitsuaki
The Third Department Of Internal Medicine Faculth Of Medicine University Of Tokyo
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Ishibashi Miyuki
The Third Department Of Internal Medicine Faculth Of Medicine University Of Tokyo
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Nakaoka Hideaki
The Institute For Adult Diseases Asahi Life Foundation
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Isobe Mitsuaki
東京大学 第3内科
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Nakaoka Hidemitsu
Third Department Of Medicine University Of Tokyo
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Kitahara Younosuke
The Institute For Adult Diseases Asahi Life Foundation
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Fujii Jun
The Institute for Adult Diseases, Asahi Life Foundation
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YAMAJI TOHRU
The Third Department of Internal Faculty of Medicine, University of Hongo
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