Altered Cyclic AMP Responsiveness to Vasopressin in Rat Renal Medullary Dispersed Cells by Acute Elevation of Endogenous Vasopressin
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概要
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Medullary and cortical tubular cells were prepared from rat kidneys with collagenase treatment. Arginine vasopressin (AVP) stimulated cyclic AMP production both in medullary and cortical cells with a dose-response relationship at concentrations ranging from 10μU/ml to 10 mU/ml, whereas parathyroid hormone (PTH) and calcitonin did only in the latter. Using this medullary cell system, effects of acute changes in endogenous plasma AVP levels <I>in vivo</I> on its cyclic AMP responsiveness to AVP (10 mU/ml) <I>in vitro</I> were examined. Acute elevation of plasma AVP levels induced by <I>ip</I> injection of 20%(w/v) polyethylene glycol-isotonic saline solution 3 h prior to sacrifice resulted in a 33% decrease in cyclic AMP responsiveness to AVP (desensitization). More prolonged elevation of plasma AVP levels by water restriction for 48 h, on the other hand, increased the responsiveness by 38 to 81%, which was restored to basal levels by ad libitum intake of water for another 48 h (positive feedback regulation). These maneuvers did not alter the cyclic AMP responsiveness to PTH (10μg/ml) in cortical cells.<BR>The results suggest that AVP-stimulated adenyl cyclase in rat renal medulla may be regulated by changes in endogenous AVP levels even within the physiological range.
- 社団法人 日本内分泌学会の論文
著者
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Yamaji Tohru
The Third Department Of Internal Medicine Faculth Of Medicine University Of Tokyo
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KATAYAMA SHIGEHIRO
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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ITABASHI AKIRA
The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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